Abstract   Introduction: Inflammation and wear debris may be responsible for bone lysis   and subsequent lost in aseptic arthroplasty. Prostaglandin E2, platelet activating factor,   and histamine are important mediators of inflammatory cells. We studied   histopathological changes of cement-bone interface after using specific antagonists   of these mediators.   Methods: Left and right tibiae...

BACKGROUND The prevalence of celiac disease and the use of medications that inhibit acid secretion have both increased in recent decades. AIM To explore the association between antisecretory medication exposure and subsequent development of celiac disease. METHODS In this population-based case control study, we identified patients with celiac disease diagnosed at all pathology departments i...

A panel of four CCR5 monoclonal antibodies (mAbs) recognizing different epitopes on CCR5 was examined in CCR5-mediated cell-cell fusion assay, alone or in combination with a variety of small molecule CCR5 antagonists. Although no antagonism was observed between any of the CCR5 inhibitors, surprisingly potent synergy was observed between CCR5 mAbs and antagonists, and the synergistic activity wa...

Angiotensin-converting enzyme inhibitors (ACEi) and mineralocorticoid receptor (MR) antagonists are FDA-approved drugs that inhibit the renin-angiotensin-aldosterone system (RAAS) and are used to treat heart failure. Combined treatment with the ACEi lisinopril and the nonspecific MR antagonist spironolactone surprisingly improves skeletal muscle, in addition to heart function and pathology in a...

Computational methods have been explored for predicting agents that produce therapeutic or adverse effects in cardiovascular and hematological systems. The quantitative structure-activity relationship (QSAR) method is the first statistical learning methods successfully used for predicting various classes of cardiovascular and hematological agents. In recent years, more sophisticated statistical...

The effects of calcium, calcium antagonists, and calmodulin inhibitors on the growth of adult T-cell leukemia (ATL) cells were studied in vitro. Fresh ATL cells from patients and established ATL cell lines did not grow well in a low-calcium (less than 0.01 mM) medium. However, their growth was enhanced by the addition of calcium to the medium in a dose-dependent manner. The maximum response was...

The renin–angiotensin system (RAS) has an important role in the control of blood pressure, hypertension, diabetes, and in the regulation of salt and volume homeostasis of organisms as well as in the heart failure, and other related renal dysfunctions. Renin is the main protease enzyme of the RAS. In kidney, Juxtaglomerular (JG) cells are most important site for renin production. Renin act on An...

Substance abuse remains a major obstacle in treating HIV-infected patients. The high prevalence of drug use is responsible for lack of adherence and severe drug interactions to antiretroviral therapy in HIV positive individuals. Over the past decade, newer therapies for HIV have been developed by targeting different stages of HIV life cycle. Of importance, targeting initial binding with recepto...

Journal Compilation © 2012 Acta Dermato-Venereologica. ISSN 0001-5555 Proton pump inhibitors and H2-receptor antagonists are widely used in the treatment of peptic ulcers and gastric acid-related diseases, because of their acid production inhibitory properties. Another group of frequently prescribed drugs, statins are used to significantly decrease the serum levels of cholesterol, thus stabiliz...