Acid peptic diseases are common gastrointestinal disorders, which include gastroesophageal reflux disease, peptic ulcers, non-ulcer dyspepsia and stressrelated gastric mucosal injury. Drugs commonly used in the management of these disorders include antacids, H2 blockers, proton pump inhibitors and mucosal protective agents. In this chapter, pharmacology of these drugs will be discussed, followe...

Gastroesophageal reflux disease (GERD) is one of the most common diagnoses in daily practice. Diagnosis can be made on symptom evaluation, on pH-monitoring or on endoscopic findings. In contrast to commonly held opinion there is no strong evidence that lifestyle factors are a dominant factor in the pathophysiology of GERD. The various agents currently used for treatment of GERD include mucoprot...

The efficacy of the antacid suspension formulations and the price of the products are two important factors influencing the selection of an antacid preparation. The present work was aimed at comparing different branded and generic antacid suspensions for their effectiveness. Various tests like acid neutralizing capacity (ANC), viscosity, particle size and specific gravity were conducted for sel...

R. J. EARLAM, M.A., M.CHIR., F.R.C.S. Consultant Surgeon, The London Hospital 3. T. WRIGHT, D.M., F.R.C.P. Consultant Physician, The London Hospital S. J. W. EVANS, B.A., M.B.C.S. Honorary Lecturer in Computer Science, The London Hospital P. HILLENBRAND, M.B., B.S., M.R.C.P. Consultant Physician, Good Hope General Hospital, Sutton Coldfield, West Midlands M. J. LANCASTER-SMITH, M.R.C.P. Consult...

Intercalibrated measurements of lead in calcium supplements indicate the importance of rigorous analytical techniques to accurately quantify contaminant exposures in complex matrices. Without such techniques, measurements of lead concentrations in calcium supplements may be either erroneously low, by as much as 50%, or below the detection limit needed for new public health criteria. In this stu...

Introduction: In Ramadan, healthy adult Muslims are obliged to fast. Prolonged fasting increase gastric acid and pepsin levels, which promote the risk of duodenal ulcer perforation (DUP). Effects of Ramadan fasting on DUP have not been thoroughly studied yet, and the limited number of studies investigating the impact of Ramadan fasting on DUP yielded discrepant results. This study aimed to eval...

Even before I began high school, I can remember suffering regularly from hunger pains. These were not the normal pains of a growing boy, nor were they the result of poverty. We always had enough food, even though we were poor. Several years later at Fort Meade, Maryland, 1 developed intense stomach pains again. They were probably precipitated by stress in anticipation of combat. Fort Meade was ...

A multiple linear regression analysis was carried out on 75 inpatients with gastric ulcer. In order to elucidate the effects of various factors - endoscopic and roentgenological findings, age, sex, medical history, and drugs such as antacids, anticholinergics or both - on the healing rate, these factors were compared between those with ulcer which healed within eight weeks after treatment and t...