نتایج جستجو برای: anergy

تعداد نتایج: 1795  

Journal: :Infectious Diseases in Obstetrics and Gynecology 1998
N L Eriksen A W Helfgott

OBJECTIVE To determine the prevalence of cutaneous anergy in pregnant and nonpregnant women who are seropositive for human immunodeficiency virus. METHODS AND MATERIALS The medical records of 159 women seropositive for human immunodeficiency virus were reviewed. Demographic characteristics and tuberculin skin test results were abstracted from the chart. Tuberculin skin testing was performed b...

Journal: :The Journal of Experimental Medicine 1992
C Go J Miller

T cell activation requires two distinct signals. The first is delivered through the antigen-specific T cell receptor (TCR), and the second is provided by costimulatory molecule(s) present on the surface of the antigen-presenting cell (APC). Stimulation of T helper type 1 T cell clones through the TCR in the absence of the costimulatory activity results in a lack of interleukin 2 (IL-2) secretio...

Journal: :Journal of immunology 2000
Y Yi M McNerney S K Datta

To identify intrinsic defects in lupus, we studied short-term, CD4(+) T cell lines that were established from 16 lupus patients (active or inactive) and 15 normal subjects by stimulating once with anti-CD3, anti-CD28, and IL-2. After resting, the pure CD4(+) T cells were exposed to anergy-inducing stimulation with plate-bound anti-CD3 mAb in the absence of APC. Lupus T cells showed prolonged hi...

Journal: :The Journal of clinical investigation 1998
C A Akdis T Blesken M Akdis B Wüthrich K Blaser

The induction of allergen-specific anergy in peripheral T cells represents a key step in specific immunotherapy (SIT). Here we demonstrate that the anergic state results from increased IL-10 production. In bee venom (BV)-SIT the specific proliferative and cytokine responses against the main allergen, the phospholipase A2 (PLA), and T cell epitope-containing PLA peptides were significantly suppr...

2012
Xuguang Tai François Van Laethem Leonid Pobezinsky Terry Guinter Susan O. Sharrow Anthony Adams Larry Granger Michael Kruhlak Tullia Lindsten Craig B. Thompson Lionel Feigenbaum Alfred Singer

CTLA-4 proteins contribute to the suppressor function of regulatory T cells (Tregs), but the mechanism by which they do so remains incompletely understood. In the present study, we assessed CTLA-4 protein function in both Tregs and conventional (Tconv) CD4 T cells. We report that CTLA-4 proteins are responsible for all 3 characteristic Treg functions of suppression, TCR hyposignaling, and anerg...

2009
Thomas G. Berger Hendrik Schulze-Koops Michaela Schäfer Ester Müller Manfred B. Lutz

Immature dendritic cells (DC) represent potential clinical tools for tolerogenic cellular immunotherapy in both transplantation and autoimmunity. A major drawback in vivo is their potential to mature during infections or inflammation, which would convert their tolerogenicity into immunogenicity. The generation of immature DC from human bone marrow (BM) by low doses of GM-CSF (lowGM) in the abse...

Journal: :Cellular and Molecular Biology Letters 2014

Journal: :Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 2001

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