نتایج جستجو برای: and ns5a proteins

تعداد نتایج: 16874701  

Journal: :Journal of virology 2012
Inbar Nevo-Yassaf Yakey Yaffe Meital Asher Orly Ravid Sharon Eizenberg Yoav I Henis Yaakov Nahmias Koret Hirschberg Ella H Sklan

Replication and assembly of hepatitis C virus (HCV) depend on the host's secretory and lipid-biosynthetic machinery. Viral replication occurs on endoplasmic reticulum (ER)-derived modified membranes, while viral assembly is thought to occur on lipid droplets (LDs). A physical association and coordination between the viral replication and assembly complexes are prerequisites for efficient viral ...

2016
Nannan Zhou Dennis Hernandez Joseph Ueland Xiaoyan Yang Fei Yu Karen Sims Philip D. Yin Fiona McPhee

BACKGROUND Daclatasvir is an NS5A inhibitor approved for treatment of infection due to hepatitis C virus (HCV) genotypes (GTs) 1-4. To support daclatasvir use in HCV genotype 4 infection, we examined a diverse genotype 4-infected population for HCV genotype 4 subtype prevalence, NS5A polymorphisms at residues associated with daclatasvir resistance (positions 28, 30, 31, or 93), and their effect...

2016
Kuan-Ying Lee Yi-Hung Chen Shih-Chin Hsu Ming-Jiun Yu

Phosphorylation at serine 235 (S235) of the hepatitis C virus (HCV) non-structural protein 5A (NS5A) plays a critical role in the viral life cycle. For medical and virological interests, we exploited the HEK293T kidney cells to test 3 candidate protein kinases on NS5A S235 phosphorylation. Inhibitors that inhibit casein kinase I α (CKIα), polo-like kinase I (PlKI) or calmodulin-dependent kinase...

Journal: :Journal of virology 2005
Nicole Appel Thomas Pietschmann Ralf Bartenschlager

Nonstructural protein 5A of the hepatitis C virus (HCV) is a highly phosphorylated molecule implicated in multiple interactions with the host cell and most likely involved in RNA replication. Two phosphorylated variants of NS5A have been described, designated according to their apparent molecular masses (in kilodaltons) as p56 and p58, which correspond to the basal and hyperphosphorylated forms...

2015
Xia Jiang Tatsuo Kanda Shuang Wu Shingo Nakamoto Masato Nakamura Reina Sasaki Yuki Haga Takaji Wakita Hiroshi Shirasawa Osamu Yokosuka Ranjit Ray

BACKGROUND Hepatitis C virus (HCV) infection is one of the major causes of cirrhosis and hepatocellular carcinoma. HCV nonstructural protein 5A (NS5A) is an attractive antiviral target and plays an important role in HCV replication as well as hepatocarcinogenesis. The aim of this study was to assess the effect of HCV NS5A protein in the abrogation of apoptotic cell death induced by the proteaso...

Journal: :The Journal of general virology 1999
J Song M Fujii F Wang M Itoh H Hotta

The non-structural protein 5A (NS5A) of some hepatitis C virus (HCV) isolates has been implicated in the inhibition of the antiviral activity of interferon (IFN). In the present study, the possible inhibitory effects of NS5A from two isolates of HCV subtype 1b, HCV-1bJk and M094AJk, and their chimeric form on the antiviral activity of IFN were examined. HCV-1bJk and M094AJk are categorized as I...

Journal: :Journal of virology 1997
C Lin J W Wu K Hsiao M S Su

Hepatitis C virus encodes a large polyprotein precursor that is proteolytically processed into at least 10 distinct products, in the order NH2-C-E1-E2-p7-NS2-NS3-NS4A-NS4B-NS5A-NS5B -COOH. A serine proteinase encoded in the N-terminal 181 residues of the NS3 nonstructural protein is responsible for cleavage at four sites (3/4A, 4A/4B, 4B/5A, and 5A/5B) in the nonstructural region. NS4A, a 54-re...

Journal: :Clinical Gastroenterology and Hepatology 2021

Hepatitis C virus infection is causing chronic liver disease, cirrhosis, and hepatocellular carcinoma. By combining direct-acting antivirals (DAAs), high sustained virologic response rates (SVRs) can be achieved. Resistance-associated substitutions (RASs) are commonly observed after DAA failure, especially nonstructural protein 5A (NS5A) RASs may impact retreatment options.1–3 Data on of failur...

Journal: :Hepatology 2004
Sophie Girard Erik Vossman David E Misek Philippe Podevin Samir Hanash Christian Bréchot Laura Beretta

Most individuals exposed to hepatitis C virus (HCV) become chronically infected and are predisposed to liver disease. The mechanisms underlying viral persistence and disease progression are unknown. A role for the HCV NS5A protein in viral replication and interferon resistance has been demonstrated. To identify mechanisms affected by NS5A, we analyzed the gene expression of Huh7 cells expressin...

2018
Preethi Krishnan Gretja Schnell Rakesh Tripathi Jill Beyer Thomas Reisch Tatyana Dekhtyar Michelle Irvin Wangang Xie Bo Fu Margaret Burroughs Rebecca Redman Hiromitsu Kumada Kazuaki Chayama Christine Collins Tami Pilot-Matias

Glecaprevir and pibrentasvir are hepatitis C virus (HCV) pangenotypic inhibitors targeting NS3/4A protease and NS5A, respectively. This once-daily, fixed-dose combination regimen demonstrated high sustained virologic response 12 weeks postdosing (SVR12) rates in CERTAIN-1 and CERTAIN-2 studies in Japanese HCV-infected patients, with a low virologic failure rate (1.2%). There were no virologic f...

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