نتایج جستجو برای: alkalization

تعداد نتایج: 378  

2016
I. L. Bartek M. J. Reichlen R. W. Honaker R. L. Leistikow E. T. Clambey M. S. Scobey A. B. Hinds S. E. Born C. R. Covey M. J. Schurr A. J. Lenaerts M. I. Voskuil

Antibiotics target specific biosynthetic processes essential for bacterial growth. It is intriguing that several commonalities connect the bactericidal activity of seemingly disparate antibiotics, such as the numerous conditions that confer broad-spectrum antibiotic tolerance. Whether antibiotics kill in a manner unique to their specific targets or by a universal mechanism is a critical and con...

Journal: :The Journal of physiology 2001
D M Liu D J Adams

1. The relative permeability of the native P2X receptor channel to monovalent and divalent inorganic and organic cations was determined from reversal potential measurements of ATP-evoked currents in parasympathetic neurones dissociated from rat submandibular ganglia using the dialysed whole-cell patch clamp technique. 2. The P2X receptor-channel exhibited weak selectivity among the alkali metal...

Journal: :Neuron 2014
Kaoru Beppu Takuya Sasaki Kenji F. Tanaka Akihiro Yamanaka Yugo Fukazawa Ryuichi Shigemoto Ko Matsui

The brain demands high-energy supply and obstruction of blood flow causes rapid deterioration of the healthiness of brain cells. Two major events occur upon ischemia: acidosis and liberation of excess glutamate, which leads to excitotoxicity. However, cellular source of glutamate and its release mechanism upon ischemia remained unknown. Here we show a causal relationship between glial acidosis ...

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