BACKGROUND Studies on the role of cold agglutinins in the pathogenesis of acute ischemic stroke are scarce. We present a case of an elderly man with acute cerebral infarction probably due to cold agglutinin disease. CASE PRESENTATION On a cold morning, a 71-year-old male of Han nationality with a complaint of sudden onset left-sided weakness and difficulty in speaking was brought to the emerg...

1. A meningococcus vaccine suspended in salt solution has been given subcutaneously as a prophylactic to about 3,700 volunteers in three injections of 2,000 million, 4,000 million, and 4,000 or 8,000 million cocci at weekly intervals. 2. These doses rarely caused more than the mildest local and general reactions. Exceptionally a more severe reaction emphasized the presence of an unusual individ...

Young adult chimpanzees immunized with human blood products produced circulating antibodies which reacted with human red cells of a certain proportion of chimpanzees. In addition, agglutinins were formed which reacted with the animals' own erythrocytes. That these agglutinins were true autoantibodies was demonstrated by: (a) their ability to sensitize the animals' own erythrocytes at 37 degrees...

In rabbits immunized by the injection of suspensions of heat-killed pneumococci the results obtained as regards not only the development of agglutinating and mouse protective antibodies, but also the persistence of these bodies in the blood depend to a considerable extent upon the route of immunization and the size of the inocula. Agglutinins may appear in the sera of all the rabbits except tho...

Aim of the case report was to present a rare case of CAD with Malaria. Methods and materials were as per the clinical protocol and investigations done in the department of pathology.Cold Agglutinin Disease (CAD) is a subgroup of autoimmune Haemolytic Anemia (AIHA). Cold reactive immune globulins (agglutinins) which are directed against erythrocyte surface antigen (‘1’ antigen) are essential for...

Seven sporadic cases of ;seronegative glandular fever' have been examined in detail; five of the patients were adults aged more than 30, two were children. None showed evidence of ;incomplete' or heat-labile sheep cell agglutinins, but in three very weak, though otherwise typical, glandular fever agglutinins were detected. Three of the other four showed evidence of certain infections, but these...

Photo-oxidation (in the presence of eosin Y as a sensitizer) of isohemagglutinating sera destroyed their agglutinating activity gradually, but did not seem to convert any of the agglutinins studied into inhibiting ("incomplete" or "blocking") antibody.