نتایج جستجو برای: adjuvant candidate
تعداد نتایج: 155644 فیلتر نتایج به سال:
We developed a novel platform to express high levels of recombinant lipoproteins with intrinsic adjuvant properties. Based on this technology, our group developed recombinant lipidated dengue envelope protein domain IIIs as vaccine candidates against dengue virus. This work aims to evaluate the immune responses in mice to the tetravalent formulation. We demonstrate that 4 serotypes of recombina...
Genome-Wide Association Studies for Taxane-Induced Peripheral Neuropathy in ECOG-5103 and ECOG-1199.
PURPOSE Taxane-induced peripheral neuropathy (TIPN) is an important survivorship issue for many cancer patients. Currently, there are no clinically implemented biomarkers to predict which patients might be at increased risk for TIPN. We present a comprehensive approach to identification of genetic variants to predict TIPN. EXPERIMENTAL DESIGN We performed a genome-wide association study (GWAS...
Globo H (GH) is a hexasaccharide specifically overexpressed on a variety of cancer cells and therefore, a good candidate for cancer vaccine development. To identify the optimal carrier and adjuvant combination, we chemically synthesized and linked GH to a carrier protein, including keyhole limpet hemocyanion, diphtheria toxoid cross-reactive material (CRM) 197 (DT), tetanus toxoid, and BSA, and...
We selected the conserved sequence in the stalk region of influenza virus hemagglutinin (HA) trimmer, the long alpha helix (LAH), as the vaccine candidate sequence, and inserted it into the major immunodominant region (MIR) of hepatitis B virus core protein (HBc), and, by using the E. coli expression system, we prepared a recombinant protein vaccine LAH-HBc in the form of virus-like particles (...
This work describes the formulation design and development of a novel protein based adjuvant, a double mutant of heat labile toxin (dmLT), based on knowledge of the protein's structural integrity and physicochemical degradation pathways. Various classes of pharmaceutical excipients were screened for their stabilizing effect on dmLT during exposure to thermal and agitation stresses as monitored ...
background and objectives: glycoprotein 96 is the primary chaperone of the endoplasmic reticulum. immunization with it induced potent cytotoxic t lymphocyte responses to intracellular bacteria. s. typhimurium is a facultative intracellular bacterium and acquired resistance against this bacterium mainly depends on activity of cytotoxic t cells. this study aimed to evaluate the capacity of glycop...
conclusions the results indicated that dt increased anti-ops antibodies against the ops-dt compound. the antibody response to ops-dt was greater than that to ops alone. we conclude that ops-dt is an appropriate and acceptable vaccine candidate against salmonellosis. results two weeks after the first vaccination dose, there was no significant difference in the antibody titers of the ops and ops-...
fibroblast growth factor 2 (fgf2) serves in the uterine endometrium during estrous presenting in the bovine mammary gland which is responsible to express interferon-t (ifnt), and is an important agent to encourage the continuation of pregnancy in the ruminants. significant associations have been found between genes affected by ifnt and genes that are responsible for milk production traits. seme...
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