Periodontitis is a common chronic inflammatory disease driven by the interaction between dysbiotic oral microbiome and dysregulated host immune-inflammatory response. Naturally derived nutraceuticals, such as resveratrol its analogs, are potential adjunctive therapies in periodontal treatment due to their antimicrobial anti-inflammatory properties. Furthermore, different analogs of choice solve...

Although scaling and root planing is a cost-effective approach for initial treatment of chronic periodontitis, it fails to eliminate subgingival pathogens and halt progressive attachment loss in some patients. Adjunctive use of systemic antibiotics immediately after completion of scaling and root planing can enhance the degree of clinical attachment gain and probing depth reduction provided by ...

AIM Human periodontitis is associated with overactivation of complement, which is triggered by different mechanisms converging on C3, the central hub of the system. We assessed whether the C3 inhibitor Cp40 inhibits naturally occurring periodontitis in non-human primates (NHPs). MATERIALS AND METHODS Non-human primates with chronic periodontitis were intra-gingivally injected with Cp40 either...

Introduction: Due to penetration of pathogenic bacteria into the periodontal tissues in moderate to severe periodontitis, the mechanical methods are not sufficient in these cases. Therefore, administration of local/systemic antibiotic is recommended following mechanical root debridement. However, side effects of antibiotics such as microbial resistance and patient allergy led to development of ...

Adjunctive therapeutic strategies that modulate the inflammatory mediators can play a significant role in periodontal therapy. In this double-blind, placebo-controlled study, 60 subjects diagnosed as periodontitis patients were evaluated for 28 days after periodontal treatment combined with selective cyclooxygenase-2 (COX-2) inhibitor. The experimental group received scaling and root planning (...

Objective: Adjunctive therapy is often used for treatment of major depressive disorder (MDD) following an inadequate response to an antidepressant. However, there is little information regarding its practice within primary care in the United Kingdom (UK). Objectives of the study were to examine incidence and predictors of adjunctive pharmacotherapy among patients with MDD treated with selective...

 The Comprehensive Periodontal Therapy Statement provides an overview of the components that should constitute efficient and effective periodontal treatment, including: o Scope of periodontal therapy o Periodontal evaluation o Establishing a diagnosis, prognosis, and treatment plan o Informed consent and patient records o Treatment procedures o Evaluation of therapy o Factors modifying results...

Purpose: The current clinical study was conducted to evaluate and biochemical effects of photodynamic therapy in treatment periodontal disease. Material methods: on twenty-eight (28) sites fourteen (14) patients. A spilt-mouth design used, were randomly selected from each patient, assigned into two groups:(control group A) received scaling root planning only, (test B): PDT (Curcumin as photosen...