We have sought to identify candidate substrates for src family protein-tyrosine kinases potentially important for transformation. Transfected NIH/3T3 cells, each overexpressing a normal or activated version of the fyn, fgr, or src translational product, were examined using antibody to phosphotyrosine as a probe. Expression of each cDNA induced similar but distinct patterns of tyrosine phosphory...

The binding of growth factors to their cognate receptors at the plasma membrane elicits a variety of biochemical and genomic changes that lead ultimately to cell proliferation or to differentiation. One of the cellular responses is the transcriptional activation of immediate-early genes. While much attention has focused on the identification and characterization of these genes, the mechanisms l...

Dual-specificity phosphatase 2 (DUSP2) regulates the activation of members mitogen-activated protein kinase (MAPK) family, which is involved in a variety cellular processes including cell proliferation, differentiation, apoptosis, and migration. DUSP2 also expression inflammatory mediators macrophages; however, it remains unknown whether participates macrophage Here, using tail fin injury model...

Osteoarthritis is the fourth leading cause of disability affecting more than 300 million people around globe. In this disease, chondrocytes responsible for growth and maintenance articular joints start to deplete due rogue involvement phosphoinositide 3-kinase, protein kinase-B p38 mitogenactivated kinases. Presently, there are medications providing symptomatic treatment, however, they cannot t...

We have identified in rabbits two hepatic forms of T669 peptide kinases that are very strongly activated after systemic injection with the inflammatory cytokiue interleukin 1 (ID1). The T669 peptide contains a major phosphoryhtion site of the epidermal growth factor receptor, threonine 699 and is a substrate for mitogen-activated protein (MAP) kinases. The kinases were purified to homogeneity a...