The penetration of solar H Lyman-α radiation into the terrestrial middle atmosphere is studied in detail. The Lyman-α actinic flux is calculated with a Monte Carlo approach including multiple resonance scattering of Lymanα photons within the terrestrial atmosphere and a temperature dependent absorption cross section of molecular oxygen. The dependence of the actinic flux on the temperature prof...

BACKGROUND Fibroblast growth factor (FGF) is involved in skin tumorigenesis: it promotes cell viability, induces angiogenesis and stimulates invasiveness. Dobesilate is a drug that blocks the activity of FGF. The primary objective was to evaluate the efficacy and tolerability of potassium dobesilate 5% cream in the treatment of actinic keratoses. METHODS Potassium dobesilate 5% cream was appl...

Ingenol mebutate gel (Picato) for actinic keratoses.

Chronic actinic dermatitis is a chronic photosensitivity disorder characterized by severe eczematous lesions on sun-exposed skin areas. We report a case of chronic actinic dermatitis presenting with leonine facies and secondary adrenal insufficiency, which was successfully treated with topical tacrolimus. The facial lesions dramatically improved after sun avoidance and topical tacrolimus applic...

To the Editor, Merkel cell carcinoma (MCC) commonly presents as a malignancy confined to the dermis. Fewer than 10% of cases show varying degrees of epidermal involvement.1 Only a small number of cases of entirely intraepidermal ‘in situ’ MCC (MCCIS) have been reported.2– 8 All but one7 of these cases were encountered as an incidental histopathological finding in the presence of an otherwise co...

The evidence for PDT in individuals who have nonhyperkeratotic actinic keratoses includes randomized controlled trials (RCTs). Relevant outcomes are symptoms, change in disease status, quality of life, and treatment-related morbidity. Evidence from multiple RCTs has found that PDT improves the net health outcome in patients with nonhyperkeratotic actinic keratoses on the face or scalp compared ...

ADVICE: following a full submission fluorouracil 0.5% / salicylic acid 10% cutaneous solution (Actikerall®) is accepted for use within NHS Scotland. Indication under review: the topical treatment of slightly palpable and/or moderately thick hyperkeratotic actinic keratosis (grade I/II) in immunocompetent adult patients. Fluorouracil 0.5% / salicylic acid 10% cutaneous solution was superior to a...

BACKGROUND The studies found in the literature associate the immunoexpression of hMLH1 and hMSH2 proteins with histologic aspects, but do not correlate it with clinical and epidemiological data. OBJECTIVE To evaluate the immunoexpression of hMLH1 and hMSH2 in actinic cheilitis, correlating it with clinical characteristics. METHODS We analyzed 40 cases. Histological and immunohistochemical a...

Chemotherapy-induced inflammation of actinic keratosis can present in patients with subclinical actinic keratoses that become erythematous and pruritic within weeks of initiating systemic chemotherapy. The reaction is limited to sun-exposed areas and, classically, histologic findings of parakeratosis and epidermal necrosis with keratinocyte nuclear pleomorphism are present. Exuberant reactions ...