نتایج جستجو برای: actin gene

تعداد نتایج: 1174543  

Journal: :Nucleic acids research 1990
L DesGroseillers D Auclair L Wickham

We present the complete nucleotide sequence of an Aplysia californica actin cDNA gene isolated from an abdominal ganglion cDNA library (Miles.M. and Scheller.R.H., Stanford University; unpublished) (Fig. 1). Using PCR technology, we showed that this actin cDNA is expressed in the sheath surrounding the neurons (probably in the muscular cells of the sheath), while another homologous actin gene i...

Journal: :Biochemistry 2014
Surinder M Singh Swati Bandi Steve J Winder Krishna M G Mallela

The structural determinants of the actin binding function of tandem calponin-homology (CH) domains are poorly understood, particularly the role of individual domains. We determined the actin binding affinity of isolated CH domains from human utrophin and compared them with the affinity of the full-length tandem CH domain. Traditional cosedimentation assays indicate that the C-terminal CH2 domai...

2010
Shuichi Takeda Shiho Minakata Ryotaro Koike Ichiro Kawahata Akihiro Narita Masashi Kitazawa Motonori Ota Tohru Yamakuni Yuichiro Maéda Yasushi Nitanai

The actin capping protein (CP) tightly binds to the barbed end of actin filaments, thus playing a key role in actin-based lamellipodial dynamics. V-1 and CARMIL proteins directly bind to CP and inhibit the filament capping activity of CP. V-1 completely inhibits CP from interacting with the barbed end, whereas CARMIL proteins act on the barbed end-bound CP and facilitate its dissociation from t...

2002
C. Lloyd

We have examined the role of feedbackregulation in the expression of the nonmuscle actin genes. C2 mouse myoblasts were transfected with the human ~and ~-actin genes. In ~-actin transfectants we found that the total actin mRNA and protein pools remained unchanged. Increasing levels of human T-actin expression resulted in a progressive down-regulation of mouse/~and ~/-actin mRNAs. Transfection o...

Journal: :Frontiers in Veterinary Science 2021

African swine fever virus (ASFV) has been identified as the agent of fever, resulting in a mortality rate nearly 100% domestic pigs worldwide. Protein p22 encoded by gene KP177R reported to be localized at inner envelope virus, while function remains unclear. In this study, interacting proteins host were high-throughput method and analyzed Gene ontology terms Kyoto Encyclopedia Genomes (KEGG) p...

Journal: :Human molecular genetics 2013
Julien Ochala Hiroyuki Iwamoto Gianina Ravenscroft Nigel G Laing Kristen J Nowak

Multiple congenital myopathies, including nemaline myopathy, can arise due to mutations in the ACTA1 gene encoding skeletal muscle α-actin. The main characteristics of ACTA1 null mutations (absence of skeletal muscle α-actin) are generalized skeletal muscle weakness and premature death. A mouse model (ACTC(Co)/KO) mimicking these conditions has successfully been rescued by transgenic over-expre...

2011
Shoichiro Ono Kazumi Nomura Sadae Hitosugi Domena K. Tu Jocelyn A. Lee David L. Baillie Kanako Ono

Disassembly of actin filaments by actin-depolymerizing factor (ADF)/cofilin and actin-interacting protein 1 (AIP1) is a conserved mechanism to promote reorganization of the actin cytoskeleton. We previously reported that unc-78, an AIP1 gene in the nematode Caenorhabditis elegans, is required for organized assembly of sarcomeric actin filaments in the body wall muscle. unc-78 functions in larva...

Journal: :The Biochemical journal 2012
Keiko Kawauchi Wee Wee Tan Keigo Araki Farhana Binte Abu Bakar Minsoo Kim Hideaki Fujita Hiroaki Hirata Yasuhiro Sawada

Actin dynamics are implicated in various cellular processes, not only through the regulation of cytoskeletal organization, but also via the control of gene expression. In the present study we show that the Src family kinase substrate p130Cas (Cas is Crk-associated substrate) influences actin remodelling and concomitant muscle-specific gene expression, thereby regulating myogenic differentiation...

Journal: :Genetics 1989
P Novick B C Osmond D Botstein

Suppressors of a temperature-sensitive mutation (act1-1) in the single actin gene of Saccharomyces cerevisiae were selected that had simultaneously acquired a cold-sensitive growth phenotype. Five genes, called SAC (suppressor of actin) were defined by complementation tests; both suppression and cold-sensitive phenotypes were recessive. Three of the genes (SAC1, SAC2 and SAC3) were subjected to...

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