Zinc-binding protein-89 (ZBP-89; ZNF148, BERF-1, BFCOL-1) is a zinc-finger transcription factor of the Kruppel family. It has been shown to regulate the expression of a number of genes, acting as either an activator or repressor of gene expression, depending on the context. It is over-expressed in several cancers, but has been shown to be involved in apoptosis and to have a negative influence o...

The aim of this study was to explore prognostic factors for non-small cell lung cancer (NSCLC) patients with brain metastases (BM) on the basis of EGFR mutation status. Among 779 consecutive NSCLC patients who underwent EGFR mutation screening, all 197 patients with BM were divided according to the EGFR mutation status. The prognostic factors, including patient characteristics at the time of BM...

INTRODUCTION To offer patients with EGFR mutation-positive advanced NSCLC appropriate EGFR tyrosine kinase inhibitor treatment, mutation testing of tumor samples is required. However, tissue/cytologic samples are not always available or evaluable. The large, noninterventional diagnostic ASSESS study (NCT01785888) evaluated the utility of circulating free tumor-derived DNA (ctDNA) from plasma fo...

BACKGROUND Mutations in the BRCA2 gene are associated with an increased risk of prostate cancer, but it is not known whether they are associated with progression of the disease. We compared prostate cancer-specific survival, disease stage, and tumor grade between prostate cancer patients carrying the Icelandic BRCA2 999del5 founder mutation and noncarriers. METHODS Using population-based regi...

This paper describes a prototype system for the prediction of parameters associated with a geological prospect, required for assessing the likelihood of hydrocarbons at the prospect. A principle characteristic of expert reasoning in this domain involves the recall and use of previous examples (`exemplars') of similar, already-drilled wells in addition to the use of general rules concerning know...

Shlomo Morant Self stabilizing protocols for distributed systems in the shared memory model are defined and studied. The protocols presented here improve upon previous protocols in two ways: Ftrst, it is assumed that the only atomic ol>erations are either read <r write ~ the shared memory. Second, our protocols work for dynamic networks, in which the topology of lhe network may change during th...

Photon (light) technology has already been widely used in make-up, medical treatment etc, but repelling mosquitoes by photon technology is an innovation. The objective of this study was to determine the efficacy of a mosquito repelling lamp, E Da under indoor conditions. E Da lamp is a lamp coated with yellow luminous pigment on the inner part of the glass bulb of the lamp which is used to scre...

and Course Syllabus Abstract The aim of this course is to teach the basic principles and concepts of modern cryptography. The focus of the course will be on cryptographic problems and their solutions, and will contain a mix of both theoretical and applied material. We will present definitions of security and argue why certain construction meet these definitions. However, these definitions and a...

2008. Is spread of invasive species regulated? Using ecological theory to interpret statistical analysis. Appendix A. Technical note on testing random walk hypotheses, derivation of dynamics under "spread regulation" of new-site ratios, models used for simulated spread scenarios, and mathematical approximation showing approximate "spread regulation" expected slope of-1. A1. Statistical testing ...