In this study, we demonstrate the antioxidant and protective properties of the aqueous extract of two commercial Polydiaceae plants - Drynaria fortunei (DF) and Pseudodrynaria coronans (PC) against 6-hydroxydopamine (6-OHDA)-induced oxidative damage in B35 neuroblastoma cells. The contents of their phytochemical profiles were determined by spectrophotometric methods and high performance liquid ...

Increased oxidative stress in the human brain is observed neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s (AD), considered to be a major cause of progression these states. A very long-chain fatty acid, nervonic acid (NA), main found various sphingolipid species central nervous system. NA plays an important role forming plasma membrane’s lipid bilayer maintaining norm...

The neuroprotective effects of environmental enrichment and PACAP (pituitary adenylate cyclase-activating polypeptide) are well-described in Parkinson’s disease. aim our study is to investigate the beneficial these factors aging parkinsonian rats. Newborn Wistar rats were divided into standard enriched groups according their conditions. Standard animals raised under regular During first five po...

Animal studies investigating the efficacy of neurotrophic factors as treatments for Parkinson's disease (PD) ideally require partial dopamine (DA) lesion models. The intrastriatal 6-hydroxydopamine (6-OHDA) lesion model may be suitable for this purpose. Although this model has been well characterized in rodents, it has not previously been used in monkeys. The goal of the present study was to ch...

Maternal stress is common during pregnancy and the postnatal period. This stress typically activates the sympathetic nervous system which releases catecholamines. This study explored the influence of sympathectomy by using neurotoxin 6-hydroxydopamine (6-OHDA) on embryo implantation, and investigated the influence mechanism of sympathectomy on reconstruction of endometrial structure during earl...

Parkinson's disease has traditionally been viewed as a motor disorder caused by the loss of dopamine (DA) neurons. However, emotional and cognitive syndromes can precede the onset of the motor deficits and provide an opportunity for therapeutic intervention. Potassium channels have recently emerged as potential new targets in the treatment of Parkinson's disease. The selective blockade of small...

Oxidative stress has been implicated as one of the causes in cell death in many neurodegenerative disorders. Due to antioxidative properties in vitro, the use of flavonoids and other polyphenolic compounds synthesised by plants are considered to be a promising strategy to prevent Alzheimer’s disease and Parkinsons’s disease. In the present study, we tested protective effects of some polyphenols...

Objectives: We aimed to investigate the neuroprotective effects of linagliptin in an vitro 6-hydroxydopamine (6-OHDA) Parkinson’s disease model. Methods: 6-OHDA (200 µM) were administered SH-SY5Y cells for 24 h induce model vitro. Cells treated with (1, 10, 50 and 100 nM) 30 minutes before administration. Cell viability was examined by 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromi...

Parkinson’s disease (PD) is characterized by progressive dopaminergic neuron loss or dysfunction and the second most prevalent neurodegenerative disorder after Alzheimer’s disease. However, current therapeutic strategies for PD are limited to treating outcomes of this rather than preventing it. Sinapic acid (SA) a phenolic compound with potential antioxidant properties, which reportedly acts as...

Background and Purpose Microglia-related inflammation is associated with the pathology of Parkinson's disease. Functional voltage-gated sodium channels (VGSCs) are involved in regulating microglial function. Here, we aim to investigate effects scorpion venom heat-resistant synthesized peptide (SVHRSP) on 6-hydroxydopamine (6-OHDA)-induced disease-like mouse model reveal its underlying mechanism...