Lung cancer, the most prevalent cancer worldwide and malignant mesothelioma are highly aggressive tumors that are characterized by high levels of matrix metalloproteinase (MMP)-2 and -9 secretion. Proteases play a key role in tumor cell invasion and metastasis by digesting the basement membrane and ECM components. Strong clinical and experimental evidence demonstrates association of elevated le...

nano-silver (agnp) has biological properties which are significant for consumer products, food technology, textiles and medical applications (e.g. wound care products, implantable medical devices, in diagnosis, drug delivery, and imaging). for their antibacterial activity, silver nanoparticles are largely used in various commercially available products. thus, the use of nano-silver is becoming ...

objective(s): glioblastoma is the most lethal tumor of the central nervous system. here, we aimed to evaluate the effects of exogenous delivery of p53 and a nanoformulation of curcumin called dendrosomal curcumin (dnc), alone and in combination, on glioblastoma tumor cells. materials and methods: mtt assay was exploited to measure the viability of u87-mg cells against dnc treatment. cells were ...

objective(s):marine organisms are known as a potential source of natural products, which contain bioactive substances with therapeutic properties. sea cucumbers are prominent among marine organisms because of their dietary and therapeutic applications. in addition, they have capacity of synthesizing saponins molecules and other metabolites with therapeutic properties such as antitumor, antimicr...

background and objectives: electric, magnetic and electromagnetic fields can act as stress factors with different effects on biological systems. due to the nutritional and medicinal values, and the increasing electromagnetic radiations, the present study was performed to investigate the effects of the electromagnetic field on the developmental stages and cytotoxic properties of okra. methods: b...

background glioblastoma is a type of brain tumor with poor response to available therapies, and shows high rate of mortality. despite remarkable advancements in our knowledge about cytogenetic and pathophysiologic features of glioblastoma, current treatment strategies are mainly based on cytotoxic drugs; however, these therapeutic approaches are facing progressive failure because of the resista...

introduction: electroporation is a practical technique used to transport the molecules across the cell membrane. the utilization of fluorescent molecules is the method widely used to evaluate the electropermeability of cell membrane as a result of pulse application. it is also possible to use mathematical methods to predict the changes caused in cell electropermeability as a result of the chang...

ovarian cancer is one of the major causes of death in women. parabens are a class of chemicals widely used as preservatives in cosmetic and pharmaceutical products, they mimic estrogens, which are known to play a role in the development of different cancers in women. the aim of this study was to investigate the proliferative effects of methyl paraben (mp) and propyl paraben (pp) on human ovaria...

We investigated the role of PI3Kγ in oral carcinogenesis by using a murine model squamous carcinoma generated exposure to 4-nitroquinoline 1-oxide (4NQO) and continuous human cancer cell line HSC-2 Cal-27. knockout (not expressing PI3Kγ), kinase-dead (carrying mutation gene causing loss kinase activity) wild-type (WT) C57Bl/6 mice were administered 4NQO via drinking water induce carcinomas. At ...