Chitosan and Agaricus blazei Murill (ABM) extracts possess antitumor activities. The aim of the present study was to investigate whether chitosan, ABM extract or the two in combination were effective against tumors in tumor‑bearing mice. The mice were subcutaneously injected with SK-Hep 1 cells and were then were divided into the following six groups: Group 1, control group; group 2, chitosan 5...

By D. Hoelzer, E. Thiel, H. L#{246}ffler, H. Bodenstein, L. Plaumann, T. B#{252}chner, D. Urbanitz, P. Koch, H. Heimpel, R. Engelhardt, U. Muller, F.-C. Wendt, H. Sodomann, H. R#{252}hl, F. Herrmann, W. Kaboth, H. Dietzfelbinger, H. Pralle, Ch. Lunscken, K.-P. Hellriegel, S. Spors, R.M. Nowrousian, J. Fischer, H. F#{252}lle, P.S. Mitrou, M. Pfreundschuh, Ch. G#{246}rg,B. Emmerich, W. Queisser, ...

Purpose: Recently, seven diffuse large B-cell lymphoma (DLBCL) genotypes were defined, among which the A53 type showed adverse outcomes. Thus, it is necessary to explore promising anticancer drugs and therapies for TP53 dysfunction patients. APR-246 a compound combat mutant p53 in solid hematological tumors, but effect of on DLBCL remains unclear. Methods: A set 2464 cases from multiple cohorts...

The general overexpression of p53 by different types of tumor cells suggests that p53 immunity might be generally useful for tumor immunotherapy. We describe here the induction of immunity to p53 and resistance to tumor metastasis using an idiotypic network. Mice were immunized with domain-specific anti-p53 monoclonal antibodies (Ab1): PAb-248 directed to the N-terminus; PAb-246 directed to the...

ST-246 (Tecovirimat) is a small synthetic antiviral compound being developed to treat pathogenic orthopoxvirus infections of humans. The compound was discovered as part of a high throughput screen designed to identify inhibitors of vaccinia virus-induced cytopathic effects. The antiviral activity is specific for orthopoxviruses and the compound does not inhibit the replication of other RNA- and...

Dystrophin has been shown to be associated in cells with actin bundles. Dys-246, an N-terminal recombinant protein encoding the first 246 residues of dystrophin, includes two calponin-homology (CH) domains, and is similar to a large class of F-actin cross-linking proteins including alpha-actinin, fimbrin, and spectrin. It has been shown that expression or microinjection of amino-terminal fragme...

review of the literature from the era of computerized tomography scanning. J Neurosurg 2000;93:940-50. 3. Hoye SJ, Hoar CS Jr, Murray JE. Extracranial meningioma presenting as a tumor of the neck. Am J Surg 1960;100:486-9. 4. Azar-Kia B, Sarwar M, Marc JA, et al. Intraosseous meningioma. Neuroradiology 1974;6:246-53. 5. Crawford TS, Kleinschmidt-DeMasters BK, Lillehei KO. Primary intraosseous m...

A maximum degree-diameter bounded subgraph problem can be seen as a degree-diameter problem restricted to certain host graphs. In this paper, we investigate the MaxDDBS problem when the host graph is a butterfly network. We give constructive lower bounds for subgraphs of maximum degree 4, 3 and 2. ∗ Was also at Department of Mathematics, University of West Bohemia, Pilsen, Czech Republic. Decea...

References 1. C. E. Capel, Inverse limit spaces, Duke Math. J. vol. 21 (1954) pp. 233-246. 2. H. Hahn, Mengentheoretische Charakterisierung der stetigen Kurve, Sitzungsber. Akad. Wiss., Wien, vol. 123 (1914) pp. 2433-2489. 3. J. L. Kelley, General topology, New York, van Nostrand Co., 1955. 4. S. Mazurkiewicz, Sur les lignes de Jordan, Fund. Math. vol. 1 (1920) pp. 166209. 5. R. L. Wilder, Topo...