Cyclin B1, a key component in the control of cell cycle progression from G(2) to M phase, has been implicated in tumorigenesis and the development of malignancy. However, the underlying mechanism by which cyclin B1 acts as an important oncogenic molecule remains largely unknown. Here we show that ectopic expression of cyclin B1 promotes cell proliferation, enhances cell motility and migration a...

b-Blockers are widely used for hypertension treatment but must be taken daily. We have developed a novel b-blocker by targeting b1-adrenergic receptor (b1-AR) mRNA with antisense oligodeoxynucleotides (b1-ASODN). A single intravenous injection of b1-AS-ODN significantly reduced cardiac contractility and blood pressure (3865 mm Hg, P,0.05) in spontaneously hypertensive rats for 3 weeks. In the p...

The persistence of coxsackievirus B1 in the muscles of mice with coxsackievirus B1-induced chronic myositis was investigated. Neonatal CD1 Swiss mice were inoculated with a myositis-causing variant of coxsackievirus B1 (Tucson strain). Hamstring muscle samples of diseased mice obtained at various times after inoculation were examined for the presence of infectious virus, viral RNA and histologi...

Ionospheric scintillation could seriously disrupt the signal tracking of global navigation satellite systems (GNSS), further causing positioning accuracy degradation or unavailability. BeiDou system (BDS), a newly developed GNSS by China, has begun to provide positioning, navigation, and timing service. The objective present study is investigate effects ionospheric on BDS-2 BDS-3 multi-frequenc...

It has been reported previously that cyclin G1 enables cells to overcome radiation-induced G(2) arrest and increased cell death and that these effects are mediated by transcriptional activation of cyclin B1. In this study, we further investigated the mechanism by which cyclin G1 transcriptionally activates cyclin B1. Deletion or point mutations within the cyclin B1 promoter region revealed that...

Let G be a group given by the presentation 〈a1, . . . , ak , b1, . . . bk | ai = ui(b̄), bi = vi(ā) for 1 ≤ i ≤ k〉, where k ≥ 2 and where the ui ∈ F (b1, . . . , bk) and wi ∈ F (a1, . . . , ak) are random words. Generically such a group is a small cancellation group and it is clear that (a1, . . . , ak) and (b1, . . . , bk) are generating n-tuples for G. We prove for generic choices of u1, . . ....

Introduction: Parallel Transmission (PTx) offers more control over B1+ than single channel systems by independently controlling elements of transmit arrays, each with spatially distinct sensitivity patterns. The majority of PTx methods require accurate knowledge of these sensitivities, the measurement of which is often time consuming for the whole array. In this work, we exploit the observation...

A method is described for confirming the identity of aflatoxins B1 and M1 in dairy products and liver extracts on a thin layer plate. Extracts and standards containing aflatoxins B1 and M1 are spotted on 10 x 10 cm plates, which are developed 2-dimensionally in mixtures of isopropanol-acetone-chloroform. After the first development, trifluoroacetic acid-hexane (1 + 4) is sprayed on that part of...

When are two views inconsistent? First consider the case when the random strings used in these views are different, i.e. we have (R, b1, b2, ..., bq) and (R′, b1, b ′ 2, ..., b ′ q). These views are inconsistent, if for some i, j the bits bi and bj refer to the same location of the proof π, but bi 6= bj . Next consider the case when the random strings used in these views are the same, i.e. we h...

BACKGROUND The aim of the present study was to evaluate the cardiovascular effects of the novel bradykinin B1 receptor antagonist BI-113823 following myocardial infarction (MI) and to determine whether B1 receptor blockade alters the cardiovascular effects of an angiotensin II type 1 (AT1) receptor antagonist after MI in rats. METHODOLOGY/PRINCIPAL FINDINGS Sprague Dawley rats were subjected ...