نتایج جستجو برای: 17b
تعداد نتایج: 472 فیلتر نتایج به سال:
We present the data used for an integrative approach to computational modeling of proteins with large variable domains, specifically applied in this context to model HIV Env glycoprotein gp120 in its CD4 and 17b bound state. The initial data involved X-ray structure PDBID:1GC1 and electron microscopy image EMD:5020. Other existing X-ray structures were used as controls to validate and hierarchi...
A series of (E) and (Z)-ferrocenyl oxindoles were prepared by coupling substituted oxindoles to ferrocenylcarboxyaldehyde in the presence of morpholine as a catalyst. The redox behavior of these isomers was determined by cyclic voltammetry. The effects of the oxindole derivatives on the migration of human breast cancer cells were evaluated using the wound-healing assay and the Boyden chamber ce...
Estrogen receptor translocation and ornithine aminotransferase induction by estradiol in rat kidney.
Injection of a hyperphysiological dose of 17P-estradiol to the rat elicits a translocation of the cytoplasmic estrogen receptor in the kidney. This is followed, a few hours later, by an increase in the rate of ornithine aminotransferase synthesis. This increase, in turn, causes the enzyme activity to rise also a few hours later. Growth of rat kidney tumor MK3 has delayed the induction of ornith...
Preparative high pressure liquid chromatography on US-Y zeolite shape-selective molecular sieve was studied for carbon isotopic fractionation eects. We tested a standard mixture [17b, 21b(H)-hopane, 5a-cholestane] and complex natural hydrocarbon mixtures dominated by tetraand pentacyclic triterpenoids extracted from Oxford Clay shales. We con®rmed that steroids and hopanoids were separated on ...
The type 2 isoform of human 17b-hydroxysteroid dehydrogenase (17bHSD2) efficiently catalyzes the oxidative metabolism of androgens and estrogens, and it is expressed in a large series of human peripheral tissues. To obtain a better understanding of the regulation of local steroid biosynthesis and metabolism in human tissues, we have established a dual steroidogenic activity of the 17bHSD2 enzym...
A conditional tetracycline-responsive transgenic mouse model with deregulated estrogen receptor a expression in mammary epithelial cells developed ductal hyperplasia (DH), lobular hyperplasia, and ductal carcinoma in situ (DCIS) by 4 months of age. Higher proliferative rates were found in both normal and abnormal ductal and lobular structures. DH and DCIS but not normal ductal structures showed...
We report on the first observation of dineutron emission in the decay of 16Be. A single-proton knockout reaction from a 53 MeV/u 17B beam was used to populate the ground state of 16Be. 16Be is bound with respect to the emission of one neutron and unbound to two-neutron emission. The dineutron character of the decay is evidenced by a small emission angle between the two neutrons. The two-neutro...
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