introduction: the inappropriate use of broad- spectrum antimicrobials in intensive care units (icu) is a universal problem. the main goal of this study was to implement antibiotic stewardship program (abs) concentrated on vancomycin and carbapenems, in pediatric icu (picu) of sheikh hospital. as an accessory purpose we looked for the effect of abs on the rate of antibiotic administration, lengt...

Six Gram-negative, facultatively anaerobic, non-spore-forming, coccoid rod-shaped isolates were obtained from fruit powder (n=3), infant formula (n=2) and an infant formula production environment (n=1) and investigated in a polyphasic taxonomic study. Comparative 16S rRNA gene sequence analysis combined with rpoB gene sequence analysis allocated the isolates to the family Enterobacteriaceae. Th...

Dear Editor, Following the recent description of transmissible plasmid-mediated colistin resistance encoded by mcr-1 in clinical and veterinary Escherichia coli and Klebsiella pneumoniae isolates in China,1 several groups have reported mcr-1 in colistin-resistant isolates from humans and food animals across Asia2–4 to Europe.5–8 It is evident that mcr-1 has disseminated globally. We performed a...

Mobile colistin resistance (mcr) genes (mcr-1 to mcr-10) are plasmid-encoded that threaten the clinical utility of (COL), one highest-priority critically important antibiotics (HP-CIAs) used treat infections caused by multidrug-resistant and extensively drug-resistant bacteria in humans animals. For more than six decades, COL has been largely unregulated poultry sector low- middle-income countr...

Multidrug-resistant Gram-negative bacteria are a major public health threat. However, intense efforts to limit their spread, the number of multidrug resistant Gram-negative bacteria continues to increase globally. Carbapenems, the most broad-spectrum beta lactam antibiotics active against Gram-negative organisms, are very slowly hydrolyzed by most beta-lactamases. Because of their broad-spectru...

conclusions the rate of carbapenem resistant a. baumannii isolates were high in this study. since, blaoxa-58-like or mbl genes were not detected, it seems that resistance to carbapenems is related to blaoxa-23-like and blaoxa-24-like. moreover, blaoxa-23-like was the most prevalent oxacillinase (oxa) gene. most of the isolates belonged to one of the four dominant genotypes indicating clonal dis...

Carbapenemases are a growing concern worldwide since they threaten the efficacy of carbapenems, the most potent -lactam antibiotics. Nonmetallocarbapenemase class A (NMC-A) was identified in 1990 from a clinical isolate of Enterobacter cloacae, and since its first report in France (1), this rare enzyme has been found only in the United States (Seattle, WA, and New York, NY), Argentina, and Finl...

Carbapenems constitute a class of broad-spectrum antibiotics for the treatment of documented multidrug-resistant organisms and for use as empiric therapy in severe, life-threatening conditions,1,2 Hospital-acquired infections due to organisms such as Clostridium difficile and multidrug-resistant Pseudomonas aeruginosa are responsible for significant morbidity and mortality in the institutional ...