Factor XIII and fibrinogen are unusual among clotting factors in that neither is a serine protease. Fibrin is the main protein constituent of the blood clot, which is stabilized by factor XIIIa through an amide or isopeptide bond that ligates adjacent fibrin monomers. Many of the structural and functional features of factor XIII and fibrin(ogen) have been elucidated by protein and gene analysis...

Carbonic anhydrase (CA) is one of the most abundant proteins found in vertebrate erythrocytes with the majority of species expressing a low activity CA I and high activity CA II. However, several phylogenetic gaps remain in our understanding of the expansion of cytoplasmic CA in vertebrate erythrocytes. In particular, very little is known about isoforms from reptiles. The current study sought t...

A patient is described who had an inhibitor to coagulation factor XIII associated with serum autoantibodies to certain tissues. The relationship of these abnormal findings to practolol therapy suggests that this was practolol-induced lupus erythematosus. Further investigations delineating the site of action of the inhibitor to factor XIII are reported.

PREDICTING perioperative blood loss is traditionally fraught with great difficulties. Medical history is certainly crucial in the risk assessment of perioperative blood loss because it provides information on bleeding history, the use of antiplatelet drugs, and oral anticoagulation. However, so far there is no laboratory parameter that could reliably predict perioperative blood loss. According ...

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........................................................................................................................................ III POPULÄRVETENSKAPLIG SAMMANFATTNING ..................................................................... V ACKNOWLEDGEMENTS ............................................................................................................... VII LIST OF PAPERS ....

................................................................................................................... 1 ACKNOWLEDGMENTS............................................................................................. V CONTENTS................................................................................................................ VII LIST OF ACRONYMS..............................

Factor XIII A subunit was detected in U937 cells and human alveolar macrophages by immunohistology and Western blotting. U937 cells synthesize factor XIII A subunit de novo under serum-free, platelet-free conditions, as indicated by 35S-methionine labeling and immunoprecipitation. Thrombin-dependent activity was demonstrated to account for 98% of the total transglutaminase activity in U937 cell...