Scleroderma renal crisis has been documented as the presenting manifestation of systemic sclerosis sine scleroderma in pregnancy only once in the literature. Unfortunately, since scleroderma renal crisis in sine scleroderma pregnant patients is so rare, that patient expired. We present a case of a sine scleroderma pregnant patient with an initial manifestation of scleroderma renal crisis surviv...

This guidance describes how the FDA evaluates patient-reported outcome (PRO) instruments used as effectiveness endpoints in clinical trials. It also describes our current thinking on how sponsors can develop and use study results measured by PRO instruments to support claims in approved product labeling (see appendix point 1). It does not address the use of PRO instruments for purposes beyond e...

Clustering is very problematic on big data set in synchronous programming as well as time consuming. Finding optimal result from big misaligned data set is precarious because lack of seamless data pattern. This study emphasizes on reducing time fact and deployment of asynchronous program rather than synchronous model on big data. However, we provide an easy and flexible model named Unified Asyn...

Some ratio estimators for estimating the population mean of the variable under study, which make use of information regarding the population proportion possessing certain attribute, are proposed. Under simple random sampling without replacement (SRSWOR) scheme, the expressions of bias and mean-squared error (MSE) up to the first order of approximation are derived. The results obtained have been...

BUSINESS VALUE • Significant savings. MTS expects a significant reduction in TCO, due to lower hardware and support costs as well as simplified management, virtualization, lower power consumption, and lower software licensing costs. In total it expects these savings could amount to up to USD 60 million (EUR 46.5 million) over seven years when migration to x86 is complete across all Russian regions

The evaluation of dystonia requires a reliable rating scale. The widely used Fahn-Marsden Scale (F-M) has not been sufficiently tested across multiple centers and investigators. The Dystonia Study Group developed the Unified Dystonia Rating Scale (UDRS) and a Global Dystonia Rating Scale (GDS) to serve as instruments to assess dystonia severity. In this study, 25 dystonia experts evaluated the ...

BACKGROUND The provision of tobacco dependence treatment in health care settings, particularly in countries lacking a history of strong tobacco control policy implementation, is limited by continued misconceptions on the part of health professionals and decision-makers regarding its worth and efficacy. In this paper, we rebut 9 arguments against the provision of tobacco dependence treatment tha...

PURPOSE A recent laboratory study demonstrated that the ingestion of a cold/menthol beverage improved exercise performance in a hot and humid environment during 20 km of all-out cycling. Therefore, the aim of this study was to determine whether the ingestion of cold water/ice-slurry with menthol would improve performance in hot and humid outdoor conditions. METHODS Ten trained males completed...

colonoscopy without sedation