Preeclampsia (PE) is defined as new onset hypertension after 20 weeks of gestation with evidence maternal organ or uteroplacental dysfunction proteinuria. PE a leading cause death, about 55000 deaths worldwide each year. Toxic substances that damage the vascular endothelium induce PE, resulting in liver and kidney malfunction. It crucial for obstetricians to identify early possible patients who...

Neurofibromatosis type 1 (NF1) results from mutations in the NF1 tumor suppressor gene, which encodes the protein neurofibromin. NF1 patients display diverse clinical manifestations, including vascular disease, which results from neointima formation and vessel occlusion. However, the pathogenesis of NF1 vascular disease remains unclear. Vessel wall homeostasis is maintained by complex interacti...

Endothelial cells that form the inner layer of blood and lymphatic vessels are important regulators of vascular functions and centrally involved in the pathogenesis of vascular diseases. In addition to the vascular endothelial growth factor (VEGF) receptor pathway, the angiopoietin (Ang)-Tie system is a second endothelial cell specific ligand-receptor signalling system necessary for embryonic c...

Hemodialysis vascular access dysfunction is a major cause of morbidity and hospitalization in the hemodialysis population. The major cause of hemodialysis vascular access dysfunction is venous stenosis as a result of neointimal hyperplasia. Despite the magnitude of the clinical problem, however, there has been a paucity of novel therapeutic interventions in this field. This is in marked contras...

Anti-vascular endothelial growth factor (VEGF) therapies are now the first-line treatment for many ocular diseases, but some patients non-responders to these therapies. The purpose of this study was determine whether level adiponectin increased pathogenesis retinal edema and neovascularization in retina progressive vascular diseases. We examined role played by two types cells animal models whic...

Long-term success in xenotransplantation is currently hampered by acute vascular rejection. The inciting cause of acute vascular rejection is not yet known; however, a variety of observations suggest that the humoral immune response of the recipient against the donor may be involved in the pathogenesis of this process. Using a pig-to-baboon heterotopic cardiac transplant model, we examined the ...

A characteristic vascular lesion has been described in human systemic infections caused by Pseudomonas aeruginosa (Forkner et al., 1958; Margaretten et al., 1961: Rabin et al., 1961). In an attempt to elucidate its pathogenesis, experimental animals were infected with P. aeruginosa to reproduce this vascular lesion. It was found that destruction of the arterial elastic lamina was frequently ass...

Epidemiologic studies suggest that higher polyphenol intake from fruits and vegetables is associated with decreased risk for cardiovascular disease. The mechanisms explaining this observation remain unclear. This review summarizes data suggesting that flavonoids improve endothelial function and inhibit platelet aggregation in humans. The vascular endothelium is a critical regulator of vascular ...

Erysipelothrix rhusiopathiae is the causative agent of animal erysipelas and human erysipeloid. Previous studies suggested glyceraldehyde 3-phosphate dehydrogenase (GAPDH) plays a role in the pathogenesis of E. rhusiopathiae infection. We studied E. rhusiopathiae GAPDH interactions with pig vascular endothelial cells, fibronectin, and plasminogen. Recombinant GAPDH (rGAPDH) was successfully obt...

Vessels and the vascular endothelium are involved in the pathogenesis of inflammatory rheumatic diseases a family of related disorders that include rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and systemic sclerosis (SSc). In these conditions vascular involvement is very important. This chapter aims to give an overview of the prevalence of the different forms of vasculopathy/va...