Background Radical prostatectomy (RP) is frequently responsible for erectile dysfunction (ED). Post-RP patients often show insufficient response or treatment failures to PDE5 inhibitor therapy. This study was undertaken to evaluate the acute effects of the soluble guanylate cyclase (sGC) stimulator, BAY 60-4552 and vardenafil administered alone or in combination on erectile responses to electri...

The following therapies may be considered medically necessary for the treatment of pulmonary arterial hypertension (PAH/ WHO Group 1):  ambrisentan (LETAIRIS®) oral;  bosentan (TRACLEER®) oral;  epoprostenol sodium (e.g., FLOLAN®) continuous IV infusion;  Iloprost (VENTAVIS®) Inhalation via nebulizer;  macitentan (OPSUMIT®) oral;  riociguat (ADEMPAS®) oral;  sildenafil citrate (e.g., REV...

In the title cooridnation polymer, {[Cu(C(6)H(2)O(5))(C(3)H(4)N(2))(2)(H(2)O)]·3H(2)O}(n), an infinite chain is formed along [001] by linking of the Cu(C(3)N(2)H(4))(2)(H(2)O) entities with two bridging monodentate carboxyl-ate groups of two different furan-2,5-dicarboxyl-ate dianions. The geometry of the Cu(2+) ion is a square-based pyramid with the water atom in the apical position and the li...

In the title coordination polymer, {[Dy(C(10)H(13)N(2)O(8))]·3H(2)O}(n), the dysprosium(III) ion is coordinated by two N atoms and six O atoms from three different (carb-oxy-meth-yl)ethyl-ene-diamine-triacetate ligands in a distorted square-anti-prismatic geometry. The ligands connect the metal atoms, forming layers parallel to the ab plane. O-H⋯O hydrogen bonds further assemble adjacent layers...

Vesicular drug delivery systems have recently gained attention as a way of improving dosing accuracy for drugs with poor transdermal permeation. The current study focuses on utilization of the natural biocompatible vesicles to formulate vardenafil nanoethosomes (VRD-NE), for the enhancement of their transdermal permeation and bioavailability. Fifteen formulations were prepared by thin-layer eva...