There are many reasons for considering the possibility that the metabolism of citrate is interrelated with the physiological effects of vitamin D and with the equilibrium of calcium and phosphorus in the body. Hamilton and Dewar10 and Shohl'7 demonstrated that the addition of citrate to rachitogenic diets resulted in prevention or cure of rickets in rats. Subsequently, Shohl and Butler1' showed...

Metabolic acidosis often complicates chronic kidney disease (CKD) and adversely affects bone, nutrition, and metabolism. Phisitkul et al. demonstrate that sodium citrate may ameliorate kidney injury in CKD patients not on dialysis. Further, they provide evidence in humans that treatment lowers urinary endothelin levels, and hence increased endothelin may be part of the mechanism whereby acidosi...

Background: Magnesium supplementation is of value in several different medical disorders. Several kinds of Mg-salts are commercially available. Purpose: This review evaluates their bioavailability criteria such as solubility, urinary excretion, and plasma levels of magnesium from studies of different Mg-salts. Conclusion: Although methodology differences were large, the results consistently dem...

OBJECTIVES The diversity of experimental results obtained in the study of the effect of citrus juice on urinary lithogenicity moved us to study the effect of these substances in vitro and in-vivo. The in-vitro study is based on the turbidimetric method on calcium oxalate crystallization. In vivo, we studied the effect of lemon juice consumption on urinary chemistry and we tested it on calcium o...

Tiselius proposed simplified estimates of the ion-activity products of calcium oxalate, calcium phosphate, and brushite as the AP(CaOx) index, the AP(CaP) index, and the AP(Bru) index, respectively, which allowed assessment of the urinary saturation levels of these lithogenic substances. A number of urinary variables (calcium, magnesium, oxalate, phosphate, citrate, urine volume, and pH) are ne...

We reevaluated the medical records of 112 children with urolithiasis. The prevalence of this condition was 1/4.500 children admitted to our hospital. The mean age was 8.2 years and 54.4% of the afflicted patients were males. Fifty percent of the patients studied had a family history of urolithiasis. The two most frequent etiologies were urinary tract infections and metabolic disorders (hypercal...

The plasma and urine metabolome of 192 overweight 12-15-year-old adolescents (BMI of 25.4 ± 2.3 kg/m(2)) were examined in order to elucidate gender, pubertal development measured as Tanner stage, physical activity measured as number of steps taken daily, and intra-/interindividual differences affecting the metabolome detected by proton NMR spectroscopy. Higher urinary excretion of citrate, crea...