In this study, the anti-melanogenic effects of Heracleum moellendorffii Hance extract (HmHe) and the mechanisms through which it inhibits melanogenesis in melan-a cells were investigated. Mushroom tyrosinase (TYR) activity and melanin content as well as cellular tyrosinase activity were measured in the cells. mRNA and protein expression of microphthalmia-associated transcription factor (MITF), ...

BACKGROUND Panax ginseng has been used to prolong longevity and is believed to be useful for improving skin complexion. Ginsenosides are the most active components isolated from ginseng, and ginsenoside Rg3 (G-Rg3) in particular has been demonstrated to possess antioxidative, antitumorigenic, and anti-inflammatory properties. The aim of this study was to examine the ability of G-Rg3 to inhibit ...

N-Hydroxycinnamoylphenalkylamides (36H) exhibited both antioxidation and antityrosinase abilities. The compound was studied for its antioxidative properties, using a 1,1-diphenyl-2-picrylhydrazul- (DPPH-) scavenging test, a ferric ion-reducing antioxidant power assay (FRAP) assessment, and a metal-chelating power assay. The results showed that 36H had antioxidative capabilities in the DPPH-scav...

conclusions all plants could inhibit mushroom tyrosinase, but more investigations on human tyrosinase and clinical studies are needed. results the hydroalcoholic extract of p. alkekengi showed the most tyrosinase inhibitory effect with ic50 of 0.09 mg/ml vs. 0.38, 0.38 and 2.82 mg/ml of b. persicum, a. rosea and m. vulgare, respectively. m. vulgare exhibited uncompetitive inhibition and other p...

A clonally derived amelanotic melanoma cell line repeatedly has been forced to produce pigment by the inhibitor of DNA synthesis, I-/3-D-arabinofuranosylcytosine (ara-C) at sublethal levels . One ara-C-derived melanotic line has been cloned, and has continued to produce pigment for 2 years on normal medium . The inhibitor is most effective when administered to synchronized cells in four pulses ...

Introduction Melanin is a dark pigment produced by about 10% of skin cells in the innermost layer of the epidermis (1). This compound is a heteropolymer of indole derivatives and is produced inside melanosomes through a series of oxidative reactions involving the amino acid tyrosine in the presence of the enzyme tyrosinase (Fig. 1). The type and amount of produced melanin in the melanosomes gen...

Melanogenesis is a process responsible for melanin production, which is stored in melanocytes containing tyrosinase. Inhibition of this enzyme is a target in the cosmetics industry, since it controls undesirable skin conditions such as hyperpigmentation due to the overproduction of melanin. Species of the Morus genus are known for the beneficial uses offered in different parts of its plants, in...

A clonally derived amelanotic melanoma cell line repeatedly has been forced to produce pigment by the inhibitor of DNA synthesis, I-beta-D-arabinofuranosylcytosine (ara-C) at sublethal levels. One ara-C-derived melanotic line has been cloned, and has continued to produce pigment for 2 years on normal medium. The inhibitor is most effective when administered to synchronized cells in four pulses ...

Natural tyrosinase inhibitors from herbal plants are promising therapeutic agents for skincare and cosmetic products. curcuminoids exhibit weak antityrosinase properties. The structural modification of curcumin, the major curcuminoid Curcuma longa, gave 14 analogues. inhibitory activity natural modified analogues on both L-tyrosine DOPA substrates were evaluated. inhibition kinetics also undert...

Tyrosinase enzymes (Tys) are involved in the key steps of melanin (protective pigments) biosynthesis and molecules targeting binuclear copper active site on tyrosinases represent a relevant strategy to regulate enzyme activities. In this work, possible synergic effect generated by combination known inhibitors is studied. For this, derivatives containing kojic acid (KA) 2-hydroxypyridine-N-oxide...