The emergence of one of the most recently described carbapenemases, namely, the New Delhi metallo-lactamase (NDM-1), constitutes a critical and growingly important medical issue. This resistance trait compromises the efficacy of almost all lactams (except aztreonam), including the last resort carbapenems. Therapeutical options may remain limited mostly to colistin, tigecycline, and fosfomycin. ...

During the last decade, Gram-negative clinical isolates, including Enterobacteriaceae, Pseudomonas spp. and Acinetobacter spp. with decreased susceptibility to carbapenems, have been increasingly reported in Europe. Carbapenem resistance in Enterobacteriaceae may be related either to the association of a decrease in bacterial outer-membrane permeability with overexpression of b-lactamases posse...

Tängdén, T. 2012. Multidrug-Resistant Escherichia coli and Klebsiella pneumoniae: Treatment, Selection and International Spread. Acta Universitatis Upsaliensis. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 840. 72 pp. Uppsala. ISBN 978-91-554-8537-5. The prevalence of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum beta-lactamases ...

References 1 Cuzon G, Naas T, Truong H et al. Worldwide diversity of Klebsiella pneumoniae that produces b-lactamase bla KPC-2 gene. related Klebsiella pneumoniae isolates of sequence type 258 producing plasmid-mediated KPC carbapenemase in Norway and Sweden. et al. Plasmid-mediated carbapenem-hydrolyzing enzyme KPC-2 and ArmA 16S rRNA methylase conferring high-level aminoglycoside resistance i...

Background Resistance of Klebsiella pneumoniae to carbapenems is mainly associated with acquired carbapenem-hydrolyzing b-lactamases [1]. These b-lactamases can be metallo b-lactamases (IMP, VIM), expanded-spectrum oxacillinases (OXA-48), or Ambler class A enzymes (NMCA, IMI, SME, GES, and KPC) [1,2]. The most common class A carbapenemases in K. pneumoniae are the K. pneumoniae carbapenemases (...

Microbial drug resistance is a growing problem of global magnitude. In gram-negative pathogens, the most important resistance problems are encountered in Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter, with increasing trends observed for all major anti-gram-negative agents (beta-lactams, fluoroquinolones and aminoglycosides). A matter of major concern is the emergence of new beta-...

Enterobacteriaceae are major pathogens in both hospital and community. Recently the number of MDR phenotypes (multi drug resistant) increased, with the emergence of XDR phenotypes (extremely drug resistant – susceptible only to colistin and tigecycline). It is extremely important to detect and correct the reporting mechanisms for resistance. Many clinical laboratories have problems detecting ex...