In adherent cells, the relevance of a physical mechanotransduction pathway provided by the perinuclear actin cap stress fibers has recently emerged. Here, we investigate the impact of a functional actin cap on the cellular adaptive response to topographical cues and uniaxial cyclic strain. Lmna-deficient fibroblasts are used as a model system because they do not develop an intact actin cap, but...

OBJECTIVE To test the hypothesis that visual memory for faces can be dissociated from visual memory for topographical material. METHOD A patient who developed a global amnesic syndrome after acute carbon monoxide poisoning is described. A neuroradiological examination documented severe bilateral atrophy of the hippocampi. RESULTS Despite a severe anterograde memory disorder involving verbal...

In topographical global optimization a sample of points that superuniformly cover the region of interest, A, is used in combination with the function evaluations in these points to obtain a topographical graph of A from which candidate points are easily extracted for local minimizations. This paper discusses some of the problems in obtaining such a cover and presents some solutions. These solut...

This study examines the effect of the number of crimes and topographical detail on police officer predictions of serial burglars’ home locations. Officers are given 36 maps depicting three, five, or seven crime sites and topographical or no topographical details. They are asked to predict, by marking an X on the map, where they thought each burglar lived. After making their predictions on half ...

A case of paraneoplastic limbic encephalitis presenting with topographical disorientation is reported. A 70 year old woman became unable to identify familiar buildings and landscapes and could not recall the way to destinations she had known very well for years. She also showed attentional disturbance and severe anterograde amnesia. Her retrograde amnesia extended for one year at most. No other...

A landslide susceptibility map plays an essential role in urban and rural planning. The main purpose of this study is to establish a variable-weighted linear combination model (VWLC) and assess its potential for landslide susceptibility mapping. Firstly, different objective methods are employed for data processing rather than the frequently-used subjective judgments: K-means clustering is used ...

Remote sensing is recognized as a valuable tool for flood mapping due to its synoptic view and continuous coverage of the flooding event. This paper proposed a hybrid approach based on multiple endmember spectral analysis (MESMA) and Random Forest classifier to extract inundated areas in Yuyao City in China using medium resolution optical imagery. MESMA was adopted to tackle the mixing pixel pr...

A 72-year-old man with pure topographical disorientation following a focal hemorrhage in the right forceps major of splenium was assessed at 2 weeks and 3 months after the onset. Initially, he could identify familiar buildings and landmarks, but noted topographical disorientation, dysfunction in sense of quarters, and in visuo-spatial function. The improvement of topographical disorientation wa...

We describe a patient who presented with a pure topographical disorientation after a stroke involving the right mesial occipito-temporal cortex. He could not point to external unseen landmarks or draw a map of his city, while he could recognize landmarks, and judge the distance, and describe the route between pairs of landmarks of the same city. He underwent standardized cognitive tests, and 6 ...