AIMS/INTRODUCTION To investigate the efficacy and safety of vildagliptin, a potent dipeptidyl peptidase-4 inhibitor, as add-on to nateglinide, compared with switching to vildagliptin in Japanese type 2 diabetes patients poorly controlled with nateglinide. MATERIALS AND METHODS A total of 40 patients inadequately controlled with nateglinide were randomized to the switching group (n = 20, switc...

BACKGROUND Sodium arsenite can impair male reproductive function by inducing oxidative stress. Silymarin is known as a potent antioxidant. OBJECTIVE This study was performed to investigate if silymarin can prevent the adverse effect of sodium arsenite on ram sperm viability, motility and mitochondrial membrane potential. MATERIALS AND METHODS Epidydimal spermatozoa obtained from ram were di...

There is an increasing demand for dairy products, but the presence of food-spoilage bacteria seriously affects development industry. Bacteriocins are considered to be a potential antibacterial or antibiofilm agent that can applied as preservative. In this study, bacteriocin BM173 was successfully expressed in Escherichia coli expression system and purified by 2-step method. Furthermore, it exhi...

We have previously reported that microthrottle pumps (MTPs) display the capacity to pump solid phase suspensions such as polystyrene beads which prove challenging to most microfluidic pumps. In this paper we report employing a linear microthrottle pump (LMTP) to pump whole, undiluted, anticoagulated, human venous blood at 200 μl min(-1) with minimal erythrocyte lysis and no observed pump blocka...

Resiniferatoxin (RTX) is an ultrapotent synthetic TRPV1 (transient receptor potential vanilloid subtype 1) agonist with significant initial transient hyperalgesia followed by a prolonged analgesic effect in response to thermal stimulus. Using a rat model of neuropathic pain, we evaluated the effect of pretreatment with clonidine-which has been shown to relieve intradermal capsaicin-induced hype...

A thermal manikin is a useful tool to evaluate thermal environments such as clothing, houses and others. A manikin needs to have the following properties: shape and size, heat production, skin temperature, sweat rate, physiological responses and others. So far, no manikin satisfying all these criteria has been available. In the present study, a two-layer movable sweating thermal manikin was new...

Thermal formation of free radicals in flumetasone sterilized according to the pharmaceutical norms at 160, 170 and 180 °C was examined by electron paramagnetic resonance (EPR) spectroscopy. The microbiological analysis was done. Similar free radical concentrations were measured for flumetasone sterilized at 160 and 170 °C. The concentration was considerably higher than that for flumetasone ster...

the present study attempts to investigate the effect of thermal treatment at 180 °c for 8 hours on chemical changes, quality indexes and oxidative stability of three iranian common virgin olive oils (zard, mari and phishomi). oil samples were taken every 2h of heating treatment and assessed for fatty acid composition, conjugated diene value, carbonyl value, color index and oxidative stability i...