Systematic analysis of synthetic lethality (SL) constitutes a critical tool for systems biology to decipher molecular pathways. The most accepted mechanistic explanation of SL is that the two genes function in parallel, mutually compensatory pathways, known as between-pathway SL. However, recent genome-wide analyses in yeast identified a significant number of within-pathway negative genetic int...

Hybrid lethality is a deleterious phenotype that is vital to species evolution. We previously reported hybrid lethality in cabbage (Brassica oleracea) and performed preliminary mapping of related genes. In the present study, the fine mapping of hybrid lethal genes revealed that BoHL1 was located on chromosome C1 between BoHLTO124 and BoHLTO130, with an interval of 101 kb. BoHL2 was confirmed to...

OBJECTIVE This study was aimed at identifying the most common risk factors associated with suicide attempts to determine differences between risk factors present in patients regarding their low-lethality and high-fatality suicide attempts. METHOD 106 patients from both sexes who had been hospitalised in a psychiatric unit following their attempts at suicide were interviewed; they were divided...

High throughput imaging is used to assess hatching, lethality and malformations in zebrafish embryos suitable for hazard ranking of different nanomaterials.

Intensification of agricultural practices is one the most important drivers dramatic decline arthropod species. We do not know, however, relative contribution to different anthropogenic stressors that are part this process. used high-resolution dynamic landscape models and advanced spatially-explicit population modelling estimate importance insecticide use structure for dynamics a widespread ca...

Planning for and managing radiological terrorism incidents that involve the release of radionuclides from a dirty bomb requires considering the potential lifesaving impact of protective radionuclide decorporation countermeasures (e.g., lung lavage). Lung lavage therapy could prevent deaths via the pulmonary mode (which involves radiation pneumonitis and fibrosis) by reducing the radiation dose ...

AIM To test the hypothesis that lethal toxins of bacteria associated with sudden infant death syndrome (SIDS) can act synergistically. METHODS Bacteria occurring together in the nasopharynx of cases of cot death were studied. The lethal toxicity of crude toxin preparations was determined over a range of dilutions by injections into the chorioallantoic vein of the chick embryo. Toxin preparati...

The objective of the study was to elucidate 33-year trends and determinants in myocardial infarction (MI) morbidity, mortality, and lethality in Russia in 1977 to 2009. Data of WHO studies (Acute Myocardial Infarction Register and MONICA) were analyzed in three districts of Novosibirsk. MI morbidity in 25 to 64-year-old population in Russia was found to be one of the highest in the world. MI mo...