background and purpose: patients with non-transfusion-dependent beta thalassemia major (ntdtm) could reach old age, marry and have children with appropriate care. this study aimed to review the marital status and maternal-fetal outcomes of ntdtm patients at thalassemia research center (trc) of sari, iran. methods: in this study, medical records of patients with β-thalassemia major were reviewed...

OBJECTIVE To provide recommendations to physicians, midwives, genetic counsellors, and clinical laboratory scientists involved in pre-conceptional or prenatal care regarding carrier screening for thalassemia and hemoglobinopathies (e.g., sickle cell anemia and other qualitative hemoglobin disorders). OUTCOMES To determine the populations to be screened and the appropriate tests to offer to mi...

The inherited Haemoglobinopathis are autosomal recessive disorder including beta Thalassemia. Out of 200 different mutations causing β Thalassemia, IVS 1-1, IVS 1-5, Codon 41-42, Codon 8-9,and Codon 619 Bp deletion are most common in Gujarat Thalassemic patients. Rapid technique of prenatal diagnosis of only IVS 1-1, IVS 1-5 and Codon 8-9 have been standardized in our lab and Prenatal Diagnosis...

OBJECTIVE Alpha thalassemia syndromes are caused by mutations on one or more of the four α-globin genes. Mutations could be either more commonly deletional or non-deletional. As some deletions (3.7 and 4.2) cause α+-thalassemia, some cause (-20.5, MED, THAI, FIL) α0 -thalassemia. The aim of this study was to determine alpha thalassemia mutations in patients with unsolved hypochromic microcytic ...

At position 0.5 kb upstream to the &globin gene lies a repeated purine-pyrimidine sequence (AT),(T),, which exhibits a great variation in length and configuration.’ The different specific patterns of this sequence are in strict linkage disequilibrium with the 0-globin haplotype. The (AT)yT5 motif has been identified several years ago in a carrier of silent 0-thalassemia of Albanian descent.’ La...

BACKGROUND This study was designed to determine relationship between the glucose metabolism disorder (the insulin resistance and the impaired glucose tolerance) and α-thalassemia. METHODS In this historical cohort study, 80Alpha-thalassemia carriers and 80 healthy people were enrolled. The participants had no diabetes familial history and the waist circumference and blood pressure were in nor...

BACKGROUND Beta thalassemia is a preventable disease. Iran has about 20,000Patients who are homozygote for β-thalassaemia and 3,750,000 carriers. The aim of this study was to determine the prevalence of beta thalassemia minor among men who underwent premarital screening in Quchana city in Khorasan Razavi region of Iran. MATERIALS AND METHODS This research is a descriptive cross-sectional stud...

In addition to premarital screening programs, education of the general population is important in preventing hemoglobinopathies. The aim of the present study was the education of university students. Short questionnaires were applied before and after a prepared lecture. A 20-minute audiovisual education was provided including the clinical characteristics and inheritance of thalassemia and sickl...