BACKGROUND Exposure to cold weather is associated with infaust cardiovascular responses, including myocardial infarction and arrhythmias. However, the exact mechanisms of these adverse changes in the myocardium under cold stress are unknown. This study was designed to investigate the mechanisms of cardiac injury induced by cold stress in mice. METHODS The mice were randomly divided into three...

Human manganese superoxide dismutase is a mitochondrial metalloenzyme that is involved in protecting aerobic organisms against superoxide toxicity, and has been implicated in slowing tumor growth. Unfortunately, this enzyme exhibits strong product inhibition, which limits its potential biomedical applications. Previous efforts to alleviate human manganese superoxide dismutase product inhibition...

BACKGROUND AND AIMS Excessive production of reactive oxygen metabolites (ROMs) by phagocytic cells is thought to contribute to the mucosal pathology of Helicobacter pylori infection. Previously, H pylori infection was shown to have a differential effect on some gastric mucosal scavenger enzymes of ROMs-namely, mitochondrial and cytoplasmic superoxide dismutases-reflected by a large increase in ...

the present study aimed to evaluate the protective effect of crocin on gastric mucosal lesions caused by ischemia-reperfusion (i/r) injury in rats.forty male rats were randomly divided into sham, control (i/r injury) and three crocin-pretreated groups. to induce i/r lesions, the celiac artery was clamped for 30 min and then the clamp was removed to allow reperfusion for 3 h. pretreated-rats rec...

background: non-steroidal anti-inflammatory drugs (nsaid) have been associated with antioxidant property and have been shown to improve the circulating antioxidant status on daily dosing in different inflammatory conditions. the present study was conducted to investigate the antioxidant role of meloxicam in aluminum induced oxidative stress in rat brain. methods: in the in vivo experiments, spr...

a valuable composition of mentha piperita l. essential oil is menthol that is widely used fordifferent industries. the plants were treated with different concentrations of methyl jasmonate (meja) and after 24 h were evaluated for total soluble proteins, chlorophylls (a, b, and total), malondialdehyde, carbohydrates and antioxidant enzymes (superoxide dismutase and guaiacol peroxidase). variance...

background: there is growing evidence that damage to spermatozoa by reactive oxygen species (ros) play a key role in male infertility. objective: the aim of the present study was to assess the antioxidant status of seminal plasma by measuring total antioxidant capacity (tac) and activities of catalase and superoxide dismutase (sod) in men with asthenozoospermia, asthenoteratozoospermia and olig...

We studied the effect of intravenously administered polyethylene glycol-conjugated superoxide dismutase (8,000 units/kg) on brain superoxide dismutase activity in 44 1-2-week-old piglets in the absence and presence of global cerebral ischemia and reperfusion. Four groups (n = 6 each) of piglets not exposed to ischemia were studied. Enzyme administration increased plasma superoxide dismutase act...

background: the possibility of impaired antioxidant status and so increased oxidative damage in periodontal disease is being conjectured. the present randomized controlled study was carried out with the objective of analyzing the activity of superoxide dismutase enzyme and thiol antioxidants in gingival crevicular fluid (gcf) and saliva as indicators of response to periodontal therapy. material...

The mechanism of the enzymic reaction of an iron-containing superoxide dismutase purified from the marine bacterium Photobacterium leiognathi was studied by using pulse radiolysis. Measurements of activity were done with two different preparations of enzyme containing either 1.6 or 1.15 g-atom of iron/mol. In both cases, identical values of the second-order rate constant for reaction between su...