Abstract Background Diabetes, a global cause of mortality in developing countries is chronic disorder affecting the metabolism macromolecules and has been attributed to defective production action insulin characterized by persistent hyperglycemic properties. This harms organs body such as liver, kidney spleen. Medicinal plants Hunteria umbellate have shown possess hypoglycemic, antioxidative an...

C-peptide is a bioactive peptide with a potentially protective role in diabetes complications; however, its molecular mechanism of protection against cardiovascular damage caused by hyperglycemia-induced apoptosis remains unclear. We investigated the protective mechanism of C-peptide against hyperglycemia-induced apoptosis using human umbilical vein endothelial cells and streptozotocin diabetic...

BACKGROUND: Stevia rebaudiana Bertoni has been used for the treatment of diabetes in, for example, Brazil, although a positive effect on antidiabetic and its complications has not been unequivocally demonstrated. This herb also has numerous therapeutic properties which have been proven safe and effective over hundreds of years. Streptozotocin is a potential source of oxidative stress that induc...

Type 2 diabetes is a chronic disease with growing public health concern globally. Finding remedies to assist this health issue requires recruiting appropriate animal model for experimental studies. This study was designated to evaluate metabolic and immunologic changes in streptozotocin-nicotinamide induced diabetic rats as a model of type 2 diabetes. Male rats were induced diabetes using nicot...

background & objectives: streptozotocin (stz) is used for induction of type-1 diabetes mellitus in animal models. its beta-cytotoxic action results in sudden release of insulin leading to severe hypoglycaemia and even mortality. however, its sensitivity varies with species. present investigation was aimed at studying stz induced acute clinical effects in rabbits. methods: streptozotocin@ 65...

Benfluorex is a pharmacological agent with antidiabetic and antihyperlipidemic properties. In this study, the brain's oxidative non-enzymatic antioxidant status in diabetic benfluorex administrated rats have been investigated. For experimental procedures, three groups of 18 Wistar albino were used as control, diabetes (induced by streptozotocin), treated (benfluorex administration intragastric ...

An experimental study was conducted top evaluate the effect of yashada bhasma in streptozotocin induced diabetes in albino rats. All the details are presented in this study.

The prevalence of type 2 diabetes mellitus (T2D) is increasing worldwide, and there are no long-term preventive strategies to stop this growth. Emerging research shows that perturbations in the gut microbiome significantly contribute development T2D, while modulators may be beneficial for T2D prevention. However, effective, safe, affordable, able administered daily not yet available. Based on o...