An efficient method for the synthesis of 1,3,5-triazines by NIS-catalyzed oxidative cyclization of alcohols with amidines has been developed. The reaction works smoothly under transition-metal free and phosphine-free conditions to afford a wide range of 1,3,5-triazine derivatives in moderate to good yields. The synthetic methodology was achieved via in situ oxidation of alcohols to aldehydes.

Base catalysed condensation of ketone 5 with different aldehydes give chalcones, 2.4-bis-(phenylamino)-6-[4'-{3''-(4'''-substituted phenyl/2'''-furanyl/2'''-thienyl)-2''-propenon-1''-yl}phenylamino]-s-thriazines 6a-e. These chalcones on cyclization with hydrazine hydrate in the presence of glacial acetic acid, guanidine nitrate in the presence of alkali and malononitrile in the presence of ammo...

This study was undertaken to find a simple and accurate structural parameters for the quantita­ tive description of inhibitory potency of 2-azido-s-triazines in Hill reaction and to gain more information about the mechanism of inhibition on molecular level. A very good correlation (r = 0.946) was obtained between the plS(> values (the negative logarithm of the molar concentra­ tion that causes ...

Mixtures of simazine, atrazine, ametryne, prometryne, deethylsimazine, deethylatrazine, hydroxysimazine, hydoxyatrazine, hydoxyprometryne, N-ethyland N-isopropylammeline, N-ethyland N-isopropylammelide, melamine, ammeline, ammelide, and cyanuric acid in aqueous solution were separated and determined in a single analysis with a detection limit of 30-400 pmol. The s-triazines were detected by a U...

The NCNN group is an essential part of various heterocycles bearing high biological activities. 1,2,4-Triazines and their condensed derivatives found applications as pharmaceuticals and in agriculture. For example vardenafil ñ phosphodiesterase inhibitor, is useful in the treatment of male erectile dysfunctions (1), apazone exhibit anti-inflammatory and analgesic actions (2), lamotrigine is use...

In the title mol-ecule, C(12)H(12)N(4)O(3)S, there is an intra-molecular O-H⋯N hydrogen bond. The dihedral angle between the benzene and triazine rings is 65.9 (3)°. In the crystal, N-H⋯S and O-H⋯N hydrogen bonds link the mol-ecules into chains along [010]. In addition, there are weak π-π stacking inter-actions between symmetry-related triazine rings with a centroid-centroid distance of 3.560 (...