It is interesting to note the way in which medical knowledge has developed over the years with regard to diseases superficially akin to classical rickets. The first stage followed as a result of the disappearance, owing to the improved knowledge of nutrition, of classical rickets as a common source of bony deformity. This led to the clearer recognition of the remaining 'resistant' forms of rick...

We present the case of a preterm 6-month-old African American infant who developed craniosynostosis secondary to rickets. This child developed rickets and macrocephaly by the age of 6 months. His head continued to enlarge, and a 3D CT obtained when the child was 2 years old revealed metopic and bilateral coronal craniosynostosis. This CT suggested increased intracranial pressure, and therefore,...

The prevalence of clinical vitamin D deficiency (rickets and osteomalacia) is high in many parts of the world, and there is a resurgence of rickets among children of ethnic minority groups in Europe and Australasia. Plasma 25-hydroxyvitamin D concentration (25OHD) is a useful risk marker of clinical vitamin D deficiency. This review summarizes the factors that contribute to differences in 25OHD...

Vitamin D deficient rickets is prevalent in Turkey and a considerable number of children are at risk of growth retardation, impaired bone formation and fracture. In order to check whether vitamin D receptor (VDR) gene polymorphism relates to the vitamin D deficient rickets, we analyzed VDR gene FokI, TaqI and ApaI polymorphisms in 24 Turkish vitamin D deficient rickets patients and 100 healthy ...

The levels of type X collagen in mineralizing normal chicken epiphyses and nonmineralizing rachitic chicken tibial epiphyses were measured and compared. Qualitative immunoperoxidase studies with anti-chick type X collagen monoclonal antibodies on sections from normal and rachitic cartilage demonstrated that the type X collagen levels in rachitic growth plates are reduced. Northern hybridization...

we studied the immune system, especially the chemotactic activity of neutrophils, in ten patients with vitamin d-deficient rickets and compared the results with ten healthy controls of matched age. among all immune system factors, the chemotactic studies persistantly showed remarkable deficiency in leukocyte mobility, both random motion and migration. when compared with controls, the findings w...

Ethnic minorities in Britain having their origins in the West Indies, the Indian sub-continent (Asian), China and Africa consume diets which differ in varying degree from those of the indigenous population. These minority groups are in general well nourished and almost certainly share obesity with the host population as their commonest nutritional problem. Infantile rickets and iron deficiency ...

Introduction Vitamin D deficiency is the major cause of rickets and osteomalacia, bone diseases which lead to several deformities of the skeleton. This paper gives a review about skeletal evidence of both diseases in Europe. First, it is necessary to explain the main principles of vitamin D metabolism in order to understand causes and effects of vitamin D deficiency. These aspects are followed ...

A 12-week-old domestic cat presented at a local veterinary clinic with hypocalcemia and skeletal abnormalities suggestive of rickets. Osteomalacia (rickets) is a disease caused by impaired bone mineralization leading to an increased prevalence of fractures and deformity. Described in a variety of species, rickets is most commonly caused by vitamin D or calcium deficiencies owing to both environ...

Vitamin D deficiency remains a global, public health concern despite intense focus in recent years. While nuanced issues such as the most appropriate cut-offs to define degrees of vitamin D sufficiency, insufficiency and deficiency are still unsettled, these debates occur on a backdrop of children continuing to be diagnosed around the world with the most devastating consequences of overt vitami...