نتایج جستجو برای: reovirus

تعداد نتایج: 1929  

Journal: :International immunology 2007
Mantej S Bharhani Jasvir S Grewal Richard Peppler Candace Enockson Lucille London Steven D London

Intestinal intra-epithelial lymphocytes (IELs) form a highly specialized lymphoid compartment. IELs consist primarily of T cells that are dispersed as single cells within the epithelial cell layer that surrounds the intestinal lumen. These lymphocytes along with lamina propria lymphocytes are considered to play an important role in the regulation of immune responses. IELs are heterogeneous with...

Journal: :Journal of virology 2002
Joseph W Golden Jessica Linke Stephen Schmechel Kara Thoemke Leslie A Schiff

Virion uncoating is a critical step in the life cycle of mammalian orthoreoviruses. In cell culture, and probably in extraintestinal tissues in vivo, reovirus virions undergo partial proteolysis within endosomal or/or lysosomal compartments. This process converts the virion into a form referred to as an intermediate subvirion particle (ISVP). In natural enteric reovirus infections, proteolytic ...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2016
Keith A Lawson Ahmed A Mostafa Zhong Qiao Shi Jason Spurrell Wenqian Chen Jun Kawakami Kathy Gratton Satbir Thakur Donald G Morris

PURPOSE In addition to their direct cytopathic effects, oncolytic viruses are capable of priming antitumor immune responses. However, strategies to enhance the immunotherapeutic potential of these agents are lacking. Here, we investigated the ability of the multi-tyrosine kinase inhibitor and first-line metastatic renal cell carcinoma (RCC) agent, sunitinib, to augment the antitumor immune resp...

Journal: :Blood 2003
Chandini M Thirukkumaran Joanne M Luider Douglas A Stewart Tina Cheng Sasha M Lupichuk Michael J Nodwell James A Russell Iwona A Auer Donald G Morris

Hematologic stem cell rescue after high-dose cytotoxic therapy is extensively used for the treatment of many hematopoietic and solid cancers. Gene marking studies suggest that occult tumor cells within the autograft may contribute to clinical relapse. To date purging of autografts contaminated with cancer cells has been unsuccessful. The selective oncolytic property of reovirus against myriad m...

2015
Victoria Roulstone Khurum Khan Hardev S. Pandha Sarah Rudman Matt Coffey Kevin J. Harrington James Spicer

Purpose: Reovirus is a wild-type oncolytic virus that is ubiquitous in the environment; most patients are therefore preimmune. Therapeutic administration leads to an increase in neutralizing antireovirus antibody (NARA) titer. We hypothesized that if NARA limited reovirus antitumor activity, the effect might be attenuated by coadministration of cyclophosphamide. Experimental design: In a phase ...

Journal: :Virology 2015
Deepti Thete Pranav Danthi

During cell entry, reovirus particles disassemble to generate ISVPs. ISVPs undergo conformational changes to form ISVP(*) and this conversion is required for membrane penetration. In tissues where ISVP formation occurs within endosomes, ISVP-to-ISVP(*) conversion occurs at low pH. In contrast, in tissues where ISVP formation occurs extracellularly, ISVP-to-ISVP(*) transition occurs at neutral p...

Journal: :The Journal of general virology 2014
Eszter Dandár Eili Huhtamo Szilvia L Farkas Miklós Oldal Ferenc Jakab Olli Vapalahti Krisztián Bányai

Orthoreoviruses have been associated with a variety of diseases in domesticated poultry and wild-living birds. In 2002, a reovirus strain named Tvärminne avian virus (TVAV), was identified in Finland in a crow showing neurological disorders. The objective of this study was the molecular characterization of this novel reovirus strain. Genome sequencing was performed by combining semiconductor se...

Journal: :Cancer research 2003
Wen Qing Yang Donna Senger Huong Muzik Zhong Qiao Shi Denise Johnson Penny M A Brasher N Barry Rewcastle Mark Hamilton Jim Rutka Johannes Wolff Cynthia Wetmore Tom Curran Patrick W K Lee Peter A Forsyth

Medulloblastoma (MB), the most common pediatric brain tumor, is a highly malignant disease with a 5-year survival rate of only 60%. Tumor cells invade surrounding tissue and disseminate through cerebral spinal fluid, making treatment difficult. Human reovirus type 3 exploits an activated Ras pathway in tumor cells to support productive infection as an oncolytic virus. Here, we examined the abil...

Journal: :The Journal of Experimental Medicine 1981
T Onodera A Toniolo U R Ray A B Jenson R A Knazek A L Notkins

Mice infected with reovirus type 1 developed transient diabetes and a runting syndrome. The diabetes was characterized by hyperglycemia, abnormal glucose tolerance tests, and hypoinsulinemia. Inflammatory cells and viral antigens were found in the islets of Langerhans, and virus particles were seen in alpha, beta, and delta cells. The runting syndrome consisted of retarded growth, oily hair, al...

Journal: :Journal of virology 2006
Sean M O'Donnell Geoffrey H Holm Janene M Pierce Bing Tian Melissa J Watson Ravi S Chari Dean W Ballard Allan R Brasier Terence S Dermody

Reovirus infection activates NF-kappaB, which leads to programmed cell death in cultured cells and in the murine central nervous system. However, little is known about how NF-kappaB elicits this cellular response. To identify host genes activated by NF-kappaB following reovirus infection, we used HeLa cells engineered to express a degradation-resistant mutant of IkappaBalpha (mIkappaBalpha) und...

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