Subtyping relapsing–remitting multiple sclerosis (RRMS) patients may help predict disease progression and triage for treatment. We aimed to subtype RRMS by structural MRI investigate their clinical significances. 155 relapse-remitting MS 210 healthy controls (HC) were retrospectively enrolled with 3DT1, diffusion tensor imaging (DTI) resting-state functional MRI. Z scores of cortical deep gray ...

We herein report the case of a 57-year-old woman presenting with a biopsy-proven tumefactive demyelinating lesion as her first clinical event. Subsequently, she displayed a relapsing-remitting course with recurrence of large demyelinating lesions exceeding 2 cm in diameter rather than the small ovoid lesions characteristic of multiple sclerosis. Administration of interferon beta did not suppres...

Following the loss of myelin from axons in multiple sclerosis, some axons recover the ability to conduct impulses despite the absence of an insulating sheath, providing a basis for remission of clinical deficits. By contrast, other axons degenerate and contribute to non-remitting clinical deficits and, thus, disability. Investigations using laboratory models of multiple sclerosis indicate that ...