Plasmodium species exhibit differential preferences for red blood cells (RBCs) of different ages. From a fundamental standpoint, we propose an age-structured within-host malaria model taking into account the variation in RBCs preference. We show that such ecological characteristic within their human host is to capture diversity same infected individual. with difference preferences, long-term co...

Here, we report the results of a study on the effects of ethanol exposure on human red blood cells (RBCs) using quantitative phase imaging techniques at the level of individual cells. Three-dimensional refractive index tomograms and dynamic membrane fluctuations of RBCs were measured using common-path diffraction optical tomography, from which morphological (volume, surface area, and sphericity...

Fluorescence techniques combined with intravital microscopy provide a powerful approach to the study of cochlear blood microcirculation. In the current study, fluorescein isothiocyanate conjugated to high molecular weight dextrans was added to plasma to enhance the visual contrast of flowing blood in microscopic images from the guinea pig cochlea. Photometric signals, obtained from video pictur...

BACKGROUND To investigate the extent of oxidative damage and changes in morphology of manually isolated red blood cells (RBCs) from whole blood, cold stored (up to 20 days) in polystyrene tubes and subjected to pre-storage irradiation (50 Gy) and to compare the properties of SAGM-preserved RBCs stored under experimental conditions (polystyrene tubes) with RBCs from standard blood bag storage. ...

The supply of transfusable red blood cells (RBCs) is not sufficient in many countries. If erythroid cell lines able to produce transfusable RBCs in vitro were established, they would be valuable resources. However, such cell lines have not been established. We developed a robust method to obtain differentiated cell lines following the induction of hematopoietic differentiation of mouse embryoni...

BACKGROUND In transfusion medicine, frozen red blood cells (RBCs) are an alternative for liquid-stored RBCs. Little is known about the rheologic properties (i.e., aggregability and deformability) of thawed RBCs. In this study the rheologic properties of high-glycerol frozen RBCs and postthaw stored in saline-adenine-glucose-mannitol medium were compared to those of conventionally liquid-stored ...

In this study, the effects of prolonged storage on several biophysical properties of red blood cells (RBCs) were investigated. Single cell deformability was used as an important criterion in determining subgroups of RBCs evolved during storage lesion. A deformability-based microfluidic cell sorting technology was applied, which demonstrates the ability to enrich and separate the less deformable...

Abstract This paper analyzes the applicability of Eringen’s Generalized Continuum Theories as a model for human blood in microcirculation. The applied theory considers fluid with fully deformable substructure, namely micromorphic fluid. analysis is motivated by fact that itself can be considered suspension particles, i.e., red cells (RBCs), suspended Newtonian fluid, plasma. As consequence, non...

The primary cause of anemia in dialysis patients is inadequate production of erythropoietin (EPO) by the dysfunctional kidneys. The EPO circulates in plasma and acts on erythroid progenitor cells in the bone marrow to produce red blood cells (RBCs). At the same time, chronic inflammatory diseases reduce the release of iron from storage sites, resulting in low transferrin saturation (Fe+ sat%). ...

Red blood cells (RBCs) contain large amounts of iron and operate in highly oxygenated tissues. As a result, these cells encounter a continuous oxidative stress. Protective mechanisms against oxidation include prevention of formation of reactive oxygen species (ROS), scavenging of various forms of ROS, and repair of oxidized cellular contents. In general, a partial defect in any of these systems...