Abstract Study question To evaluate the efficacy of Hyaluronan Enriched Media (HEM) to optimize Reproductive Outcomes in women with Recurrent Implantation Failures (RIF)? Summary answer In RIF, HEM seems offer beneficial and safer reproductive outcomes. What is known already has shown enhance implantation process an embryo in-utero. Efficacy outcomes still not proven. design, size, duration Thi...

BACKGROUND Recurrent implantation failure is one of the most issues in IVF cycles. Some researchers found that beneficial effects of endometrial Scratching in women with recurrent implantation failure, while some authors demonstrated contrary results. OBJECTIVE The present study aimed to investigate the effect of intrauterine. Saline infusion as a form of endometrial injury, during fresh in v...

OBJECTIVE Several studies have shown the improving effect of heparin on the outcomes of ART. Moreover, it has been reported that adding heparin in non-thrombophilia patients with RIF is useful.The aim of this study was to evaluate the beneficial effects of heparin on ART outcomes in women with history of recurrent implantation failure (RIF) and without history of congenital or acquired thrombop...

BACKGROUND A receptive endometrium is essential for maternal-embryonic molecular communication during implantation. However, the specific molecular regulatory mechanisms of the endometrial capacity remain poorly understood. Here, we examined activating transcription factor 3 (ATF3) expression in human endometria and the functional effect of ATF3 on embryo attachment in vitro. METHODS Immunohi...

Abstract Extracellular matrix (ECM) is characterized as widespread, abundant, and pluripotent. Among ECM members, collagen widely accepted one of the most prominent components for its essential structural property that can provide a scaffold other rich biological functions, which has been extensively used in tissue engineering. Emerging evidence shown balance degradation remodeling vital to reg...

Background We sought to compare diagnostic values of two-dimensional transvaginal sonography (2D TVS) and office hysteroscopy (OH) for evaluation of endometrial pathologies in cases with repeated implantation failure (RIF) or recurrent pregnancy loss (RPL). MATERIALS AND METHODS This prospective study was performed at Royan Institute from December 2013 to January 2015. TVS was performed befor...

Background Implantation failure is the most important cause of recurrent in vitro fertilization/intra cytoplasmic sperm injection (IVF/ICSI) failure. Several reports suggest that intercourse during the peritransfer period might improve pregnancy rates. This study is designed to determine whether intercourse during the peritransfer period will improve pregnancy and implantation rates in patients...