نتایج جستجو برای: radiotherapy induced diarrhea

تعداد نتایج: 1066786  

Journal: :The Journal of clinical investigation 2006
Daniel R Clayburgh Mark W Musch Michael Leitges Yang-Xin Fu Jerrold R Turner

Acute T cell-mediated diarrhea is associated with increased mucosal expression of proinflammatory cytokines, including the TNF superfamily members TNF and LIGHT. While we have previously shown that epithelial barrier dysfunction induced by myosin light chain kinase (MLCK) is required for the development of diarrhea, MLCK inhibition does not completely restore water absorption. In contrast, alth...

Journal: :The journal of supportive oncology 2007
Andrea M Stringer Rachel J Gibson Joanne M Bowen Richard M Logan Ann S-J Yeoh Dorothy M K Keefe

Collectively, mucositis refers to the damage caused to the mucous membranes of the body following cytotoxic cancer therapy. Diarrhea is one such manifestation of mucositis and is a common side effect of chemotherapy that remains poorly understood. It affects the entire gastrointestinal tract. The exact number of patients affected by diarrhea as a result of treatment is uncertain, although it is...

Journal: :Clinical and vaccine immunology : CVI 2015
Weiping Zhang David A Sack

Diarrhea continues to be a leading cause of death in children <5 years of age, and enterotoxigenic Escherichia coli (ETEC) is the most common bacterial cause of children's diarrhea. Currently, there are no available vaccines against ETEC-associated diarrhea. Whole-cell vaccine candidates have been under development but require further improvements because they provide inadequate protection and ...

2013
Hee Yeon Lee Youn Hee Lee Min Ji Kim Hoon-Kyo Kim

Diarrhea is a common adverse event of docetaxel with 20%-40% of incidence and severe diarrhea occurs in 5%-6%. Several treatment guidelines for chemotherapy induced diarrhea (CID) exist, however the prophylaxis for that is not well known. We describe a new prophylactic approach for the CID with loperamide. A 72-yr-old male patient with stage IV non-small-cell lung cancer developed diarrhea repe...

2018
Risako Kon Yuika Tsubota Moe Minami Saki Kato Yukari Matsunaga Hiroshi Kimura Yuta Murakami Tetsuya Fujikawa Ryoya Sakurai Rei Tomimoto Yoshiaki Machida Nobutomo Ikarashi Kiyoshi Sugiyama

While irinotecan (CPT-11) has a potent anti-cancer effect, it also causes serious diarrhea as an adverse reaction. In this study, we analyzed the pathogenic mechanism of CPT-11-induced delayed diarrhea by focusing on water channel aquaporin-3 (AQP3) in the colon. When rats received CPT-11, the expression level of AQP3 was reduced during severe diarrhea. It was found that the expression levels o...

Abdolazim Sedighi Pashaki Fahimeh Rezaie Karim Khoshgard, Mohammad Hadi Gholami

Introduction: Xerostomia is the most common complication due to radiation–induced damage to salivary glands in head and neck cancer radiotherapy and it reduces quality of life. Parotid glands are main glands which they are account for secretion of stimulated saliva. Studies have demonstrated that mean tolerance parotid’s radiation dose under 26-30 Gy result in an increase in t...

Journal: :Oncology 2000
David H Ilson Bruce Minsky

The limited effectiveness of chemotherapy in esophageal cancer used to palliate metastatic disease or to combine with radiotherapy in locally advanced disease has prompted the evaluation of new systemic agents. Irinotecan (CPT-11, Camptosar) has shown promising activity in a number of gastrointestinal cancers, including esophageal cancer. The phase II evaluation of the combination of weekly iri...

2016
Jinhong Jung Sang Min Yoon Hee Chul Park Taek-Keun Nam Jinsil Seong Eui Kyu Chie Tae Hyun Kim Mi-Sook Kim Chul Yong Kim Hong Seok Jang Jong Hoon Kim

Although the adrenal glands are not common sites of metastasis from hepatocellular carcinoma (HCC), this metastasis can be met in patients with advanced HCC in some clinical settings. However, the effectiveness of radiotherapy against such metastases is unclear. Therefore, we performed the present multi-institutional study to investigate tumor response, overall survival (OS), treatment-related ...

Journal: :Folia Pharmacologica Japonica 1959

2016
Gökçe Günaydın Shengze Yu Torbjörn Gräslund Lennart Hammarström Harold Marcotte

A variable fragment of a heavy chain antibody (VHH) directed against rotavirus, also referred to as anti-rotavirus protein 1 (ARP1), was shown to confer protection against rotavirus induced diarrhea in infant mouse model of rotavirus induced diarrhea. In this study, we have fused the mouse IgG1 Fc to ARP1 to improve the protective capacity of ARP1 by inducing an Fc-mediated effector function. W...

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