Hemopoietic cells in chronic granulocytic leukemia (CGL) frequently contain a chromosome translocation involving chromosome 22 and another autosome, usually number 9. The translocated chromosome 22 is known as the Philadelphia (Ph) chromosome. The appearance of a second Ph chromosome is the most common cytogenetic abnormality in CGL signaling the blastic phase. For 6 yr we serially studied a ma...

We have analyzed the molecular features of a t(ll;14)(q23;q32) chro mosome translocation of a cell line established from a B-cell lymphoma. Somatic hybrid cells carrying the llq— and/or 14q+ chromosome(s) were produced in order to map the breakpoints. Southern blot analyses of DNAs from these hybrid cell lines together with various probes from the IGH locus on chromosome 14 and the ETS-l and ...

Translocation t(4;11)(q21;q23) leading to formation of MLL-AF4 fusion gene is found in about 10% of newly diagnosed B-cell acute lymphoblastic leukemia (ALL) in adult patients. Patients expressing this chromosomal aberration present typical biological, immunophenotypic, and clinical features. This form of leukemia is universally recognized as high-risk leukemia and treatment intensification wit...

Human acute leukemia, with a chromosomal translocation involving chromosomes 4 and 11, t(4;llXq21;q23), is the most common form of leukemia in infants and responds very poorly to conventional therapy. A human CD19* mixed-lineage leukemia cell line with a t(4;llXq21;q23) translocation, RS4;11, disseminated and proliferated in the hematopoietic tissues and other organs of mice with severe combine...