Phyllantus amarus Schumach and Thonn is a medicinal plant used commonly for the treatment of malaria-related symptoms by the general public in southeastern Nigeria. The present study determines the possible antiplasmodial effects of the aqueous extract of the leaves and stem of the plant against Plasmodium berghei infection using Swiss albino mice as models. The blood schizonticidal activity of...

rates of gar-ganey (Anas querquedula) staging in the Camargue, southern France, during spring migration. North American ducks and gulls to H5N1 highly pathogenic avian infl uenza viruses.ment of multiple sublineages of H5N1 infl uenza virus in Asia: Implications for pandemic control. To the Editor: Malaria remains a major public health problem and a primary cause of illness in Madagas-car (1). ...

Correspondence t Davidson. The increased use of malaria prophylaxis has led to more reports of drug induced toxicity. Hepatic, renal, skin, and bone marrow effects are well recognised. Five cases of pulmonary toxicity and systemic illness after the use of pyrimethamine-sulfadoxine (Fansidar) have been reported.'-' In two of these reports rapidly progressive respiratory failure developed and ope...

Antimalarial drugs capable of targeting multiple parasite stages, particularly the transmissible can be valuable tools for advancing malaria elimination agenda. Current antifolate such as pyrimethamine inhibit replicative stages in both humans and mosquitoes, but resistance remains a challenge. The lack reliable gametocyte-producing, antifolate-resistant Plasmodium falciparum laboratory strain ...

For monitoring efficacy of sulfadoxine/pyrimethamine intermittent preventive treatment for malaria during pregnancy, data obtained from studies of children seemed inadequate. High prevalence of triple and quadruple mutants in the dihydropteroate synthase and dihydrofolate reductase genes of Plasmodium falciparum parasites contrasts with the efficacy of sulfadoxine/pyrimethamine in reducing low ...

using mutation specific pcr assay and analysis of position 108 amino acid in dihydrofolate reductase-thymidilate synthase gene in 70 plasmodium falciparum isolates of malarial patients from southern areas of iran, showed 4 different situations: iwild type (108-ser) ii-mutant type (108-thr) iii-mutant type (108-asn) and iv-mixed wild and mutant type (108-ser+thr) with frequency of 58(82.8%), 2(2...

Epidemic malaria has rapidly emerged in Loreto Department, in the Peruvian Amazon region. Peru reports the second highest number of malaria cases in South America (after Brazil), most from Loreto. From 1992 to 1997, malaria increased 50-fold in Loreto but only fourfold in Peru. Plasmodium falciparum infection, which has increased at a faster rate than P. vivax infection in the last 3 years, bec...

BACKGROUND Antifolate antimalarials like sulfadoxine-pyrimethamine are used as second-line treatment for Plasmodium falciparum malaria patients who fail to respond to chloroquine. The efficacy of the sulfa-pyrimethamine combination in the treatment is also compromised by the development of resistance in the parasite. Resistance to these drugs has been shown to encode with point mutations in dih...