نتایج جستجو برای: protein tyrosine phosphatase 1b
تعداد نتایج: 1300053 فیلتر نتایج به سال:
BACKGROUND Protein-tyrosine phosphatase 1B (PTP1B) is a physiological regulator of insulin signaling and energy balance, but its role in brown fat adipogenesis requires additional investigation. METHODOLOGY/PRINCIPAL FINDINGS To precisely determine the role of PTP1B in adipogenesis, we established preadipocyte cell lines from wild type and PTP1B knockout (KO) mice. In addition, we reconstitut...
As the prototypical member of the PTP family, protein tyrosine phosphatase 1B (PTP1B) is an attractive target for therapeutic interventions in type 2 diabetes. The extremely conserved catalytic site of PTP1B renders the design of selective PTP1B inhibitors intractable. Although discovered allosteric inhibitors containing a benzofuran sulfonamide scaffold offer fascinating opportunities to overc...
Submit Manuscript | http://medcraveonline.com Abbreviations: T1D: Type 1 diabetes; T2D: Type 2 diabetes; NIDDM: Non-Insulin-Dependent Diabetes Mellitus; TNF-α: Tumor Necrosis Factor Alpha; IRS: Insulin Receptor and Substrates; RXR: Retinoid X-Receptor; PTP1B: Protein Tyrosine Phosphatase 1B; PTPs: Protein Tyrosine Phosphatases; GPR: G-Protein Coupled Receptor; LA: Lipoic Acid; NAC: N-Acetyl-l-C...
Lymphocytes migrate from the blood into tissue by binding to and migrating across endothelial cells. One of the endothelial cell adhesion molecules that mediate lymphocyte binding is VCAM-1. We have reported that binding to VCAM-1 activates endothelial cell NADPH oxidase for the generation of reactive oxygen species (ROS). The ROS oxidize and stimulate an increase in protein kinase C (PKC)alpha...
Hassid, Aviv, Shile Huang, and Jian Yao. Role of PTP-1B in aortic smooth muscle cell motility and tyrosine phosphorylation of focal adhesion proteins. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H192–H198, 1999.—Recent studies have focused attention on the role of protein tyrosine kinases in vascular smooth muscle cell biology, but similar information regarding protein tyrosine phosphatases ...
Purified preparations of a protamine protein kinase from bovine kidney cytosol [Damuni, Amick & Sneed (1989) J. Biol. Chem. 264, 6412-6416] were inactivated after incubation with near-homogeneous preparations of protein phosphatase 2A1 and protein phosphatase 2A2. These protein phosphatase 2A-mediated inactivations of the protamine kinase were unaffected by highly purified preparations of inhib...
A series of 1H-2,3-dihydroperimidine derivatives was designed, synthesized, and evaluated as a new class of inhibitors of protein tyrosine phosphatase 1B (PTP1B) with IC50 values in the micromolar range. Compounds 46 and 49 showed submicromolar inhibitory activity against PTP1B, and good selectivity (3.48-fold and 2.10-fold respectively) over T-cell protein tyrosine phosphatases (TCPTP). These ...
Characterization of Protein Tyrosine Phosphatase 1B Inhibition by Chlorogenic Acid and Cichoric Acid
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