The inevitable adsorption of biomolecules on nanomaterials results in the formation of a protein corona (PC), which modifies the nanoparticle (NP)-cell interface resulting in modified uptake, activity, clearance, and toxicity. While the physicochemical properties of the NP govern the composition of PC, the formation of PC in turn alters the characteristics of the NP by imparting a new unique "b...

Lysophosphatidylcholine (lyso-PC) and arachidonate are products of phosphatidylcholine hydrolysis by phospholipase A(2). In this study, the modulation of arachidonate release by exogenous lyso-PC in rat heart myoblastic H9c2 cells was examined. Incubation of H9c2 cells with lyso-PC resulted in an enhanced release of arachidonate in both a time- and dose-dependent fashion. Lyso-PC species contai...

To study the consequences of depleting the major membrane phospholipid phosphatidylcholine (PC), exponentially growing cells of a yeast cho2opi3 double deletion mutant were transferred from medium containing choline to choline-free medium. Cell growth did not cease until the PC level had dropped below 2 % of total phospholipids after 4-5 generations. Increasing contents of phosphatidylethanolam...

To study the consequences of depleting the major membrane phospholipid phosphatidylcholine (PC), exponentially growing cells of a yeast cho2opi3 double deletion mutant were transferred from medium containing choline to choline-free medium. Cell growth did not cease until the PC level had dropped below 2% of total phospholipids after four to five generations. Increasing contents of phosphatidyle...

Look up at the stars and not down at your feet. Try to make sense of what you see, and wonder about what makes the universe exist. Be curious. Knowledge is relative to time and place, never absolute across time and space (Patton, 2002) Contents CONTENTS CONTENTS ABSTRACT LIST OF PAPERS

Recently, a welcome trend has emerged - in addition to the traditional studies on contents and states of consciousness, levels of consciousness have become a matter of research. However, there are some conceptual and methodological difficulties with this research - the labels used for empirical measurement of levels are ambiguous and underspecified while the research on neural correlates of con...

Simulation with integrated parameter optimization of a given model structure is a well-established technique today. However, with increasing system complexity and flexibility the number of possible structure variants increases. Therefore the potential benefit of automatic model structure optimization becomes significant. During optimization, the introduced framework supports automatic parameter...

Contents 1. Introduction 2. The problem in context — some of the man-made environmental problems with potentially catastrophic consequences for life on earth 3. How did we get here? Evolution of human attitude to nature and the natural environment 3.1.

In this study, some physiological and biochemical responses of Synechococcus elongatus to salt stress were investigated. The cyanobactrium was grown in BG-11 medium under different concentrations of NaCl (0, 0.5, 1 M). The results indicated that the growth of S. elongatus was significantly inhibited under salt stress on days 5, 9 and 12. Protein content increased in S. elongatus on day 12 in pr...