Nurse-midwives are sometimes required to intervene in the normal process of labor. Numerous clinical trials have investigated the use of prostaglandins for induction of labor. Research indicates the use of prostaglandins to be a safe and effective method of induction of labor with favorable results when compared with the more traditional use of oxytocin. Patient acceptance appears to be favorab...

Prostaglandins act as mediators of inflammation and, similar to cytokines, function as immune modulators during innate and adaptive immune responses. Therefore, using a pharmacological inhibitor, celecoxib, we investigated the role of prostaglandins in host defense against Histoplasma capsulatum infection in C57BL/6 mice. Our results showed that treatment with celecoxib inhibited cyclooxygenase...

The blood-bathed organ technique was used to detect and continuously estimate the concentration of prostaglandins E 1 , E 2 , and F 2 in the circulation, to determine their stability in tihe blood and their disappearance in different vascular beds. Prostaglandins are released into the splenic venous blood duringspleen contractions. The pulmonary circulation provides an efficient protective mech...

Caenorhabditis elegans is emerging as a powerful animal model to study the biology of lipids(1-9). Prostaglandins are an important class of eicosanoids, which are lipid signals derived from polyunsaturated fatty acids (PUFAs)(10-14). These signalling molecules are difficult to study because of their low abundance and reactive nature. The characteristic feature of prostaglandins is a cyclopentan...

Since prostaglandins have been consistently recovered from a wide range of inflammatory reactions, including cutaneous inflammation, we have studied the effect of the anti-inflammatory corticosteroids hydrocortisone and fluocinolone on in-vitro biosynthesis of prostaglandins by skin. Skin homogenates synthesized prostaglandins E(2) and F(2)alpha in the presence of an excess of arachidonic acid ...

Background: Arabica coffee ground nanoparticles gel is known to possess good physicochemical properties and high phenolic contents in which the phenolics are famous for their anti-inflammatory activities. Objectives: : This study aimed investigate activities of arabica on carrageenan-induced male mice 6 h. The positive control was commercial medicine (Voltaren gel), negative base gel. Methods: ...

Prostaglandins have stimulative influence on the human uterus and therefore were introduced to medical treatment in reproductive healthcare as labor inductors or abortifacients. The UHPLC-ESI-QqQ-MS/MS method was developed for six prostaglandins: carboprost, cloprostenol, dinoprost (PGF2α), dinoprostone (PGE2), misoprostol sulprostone (substances pregnancy termination) pharmaceutical samples ap...

Human aqueous humour was found to contain a substance which contracted the rat stomach strip. The mean activity was significantly higher in specimens from open angle glaucoma cases than in specimens from patients with cataract. The pharmacological and chromatographic properties of the active material were studied in aqueous humour obtained from cadavers; activity seemed to be due to prostagland...

Prostaglandins (PGs) are widely distributed throughout the gastrointestinal tract and affect a variety of gastrointestinal functions. The observation that PGs of the E and A series are potent inhibitors of gastric acid secretion and that PGs, especially the E compounds, are released into the gastric lumen during vagal or gastrin stimulation suggests a possible physiological role for these agent...