These studies were designed to investigate the relationship between cerebral prostanoid synthesis and pial arterial caliber in chloralose-anesthetized newborn pigs with normal blood gases and pH and during combined arterial hypoxia and hypercapnia. Piglets less than 5 days old were equipped with closed cranial windows to allow direct observation of pial vessels, application of prostaglandin E2,...

This study evaluated the effect of hyperoxia on the pharmacokinetic function of the lung. Hyperoxia is known to disrupt the activities of the pulmonary prostaglandin dehydrogenase/reductase and angiotensin converting enzymes. This would be predicted to alter the activation/deactivation of prostaglandins or angiotensin. The ability of these enzyme systems to act upon these compounds was evaluate...

STUDY DESIGN The expression of cyclooxygenase-2 was studied immunohistologically in specimens from lumbar disc herniation. The cultured disc cells also were examined to evaluate the significance of cyclooxygenase-2, which might be involved in the pathogenesis of lumbar disc herniation. OBJECTIVE To investigate whether cyclooxygenase-2 might be involved in the pathogenesis of lumbar disc herni...

Prostaglandin E2 is now widely recognized to play critical roles in brain inflammation and injury, although the responsible prostaglandin receptors have not been fully identified. We developed a potent and selective antagonist for the prostaglandin E2 receptor subtype EP2, TG6-10-1, with a sufficient pharmacokinetic profile to be used in vivo. We found that in the mouse pilocarpine model of sta...

Abstract Embryonic mortality (EM) is a major factor limiting reproductive efficiency in cattle, and despite negative connotations related to performance, prostaglandin F2α (PGF2α) capable of being released by the uterus Day 30 gestation. Therefore, objective was evaluate differences PGF2α release after an oxytocin challenge between cows with high circulating concentrations pregnancy-associated ...

Prostaglandin E2 (PGE2) is a principal fever mediator that induces hyperthermia when injected into the organum vasculosum lamina terminalis (OVLT) and the adjacent preoptic area of the hypothalamus (POA). PGE (EP) receptors have four subtypes, i.e. EP1, EP2, EP3, and EP4. In the rat OVLT/POA region, at least three of these receptors, i.e. EP1, EP3, and EP4 receptors, have distinctively differen...

Prostaglandin E2 is widely used in obstetrics and is thought to be relatively safe for cervical ripening and induction of labour. Here we present a case in which acute hemoperitoneum was observed after administration of prostaglandin E2 in a pregnant woman. The patient had a history of endometriosis, and a severe pelvic adhesion (ASRM stage IV) was found during her last laparoscopic surgery 3 y...

The peroxisome proliferator-activated receptors (PPARs) are a family of nuclear transcription factors thought to act as receptors for polyunsaturated fatty acids and to reduce production of series 2 prostaglandins (PG). The objectives of the current study were to characterize PPAR expression and the prostaglandin synthetic activity of cultured bovine endometrial cells in response to known PPAR ...