BACKGROUND The Early Detection and Intervention Programme of the German Research Network on Schizophrenia (GRNS) investigates the initial prodromal phase of psychosis in a multidimensional approach. Two intervention strategies are being studied by two large-scale multicentre projects. AIMS To present the concept of the intervention studies, and to provide an interim report of the recruitment ...

One hundred and thirty four ambulatory children with bronchial asthma were investigated in the Pediatric Pulmonary-Allergic Service. In 95 patients an interval characterised by prodromal respiratory symptoms (cough, rhinorrhoea, and wheezing), behavioural changes (irritability, apathy, anxiety, and sleep disorders), gastrointestinal symptoms (abdominal pain and anorexia), fever, itching, skin e...

OBJECTIVE Prediction of transition to psychosis in the prodromal phase of schizophrenia has raised interest in intervention prior to the onset of frank psychosis. The aim of this review was to examine whether interventions in the prodromal phase have a favourable benefit/risk ratio. METHOD A literature search in PubMed, EMBASE and PsycINFO was performed. RESULTS Three randomized clinical tr...

Erythema marginatum is a characteristic skin rash seen in patients with hereditary angioedema (HAE); however, it can be confused with urticaria, leading to delay in correct diagnosis. The aim of this study was to clarify how often erythema marginatum is misinterpreted as urticaria, potentially leading physicians to refrain from testing for HAE. Few studies have been published on urticaria and p...

FAILURES in the surgical management of malignant glaucoma (von Graefe, 1869; Smith, 1891; Chandler, 1950; McDonald, 1954) call attention to the syndrome of prodromal malignant glaucoma in which success has been reported (Birge, 1956). Based on a new and possibly radical operation performed before the devastating complications which give rise to malignant glaucoma can occur (Birge, 1952, 1953, 1...

Introduction One of the methods for early diagnosis in individuals at clinical high-risk state psychosis could be identifying specific symptoms, such as thought disorders. Thought disorders may a separate symptom, unrelated to attenuated positive symptoms (APS) with an independent predictive value. Objectives Correlation analysis and APS patients psychosis. Methods The study included 30 young m...

OBJECTIVE To predict prodromal psychosis in adolescents with velocardiofacial syndrome (VCFS). METHOD A total of 70 youth with VCFS, 27 siblings of youth with VCFS, and 25 community controls were followed from childhood (mean age = 11.8 years) into mid-adolescence (mean age = 15.0 years). Psychological tests measuring intelligence, academic achievement, learning/memory, attention, and executi...