نتایج جستجو برای: pla2 antigen

تعداد نتایج: 201520  

2016
Mohammad Hossein Boskabady Sedigheh Jalali Negin Yahyazadeh Mostafa Boskabady

OBJECTIVE Pharmacological effects of carvacrol such as its anti-inflammatory activities have been shows. In this study the effects of carvacrol on serum levels of total protein (TP), phospholipase A2 (PLA2) and histamine in sensitized guinea pigs was evaluated. MATERIALS AND METHODS Sensitized guinea pigs were given drinking water alone (group S), drinking water containing three concentration...

Journal: :Current pharmaceutical design 2011
Alexandros F Tselepis Manfredi Rizzo Ioannis A Goudevenos

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a calcium-independent phospholipase A2 that circulates in plasma in association with lipoprotein particles, whereas in atherosclerotic plaques it is co-localized with macrophages. Lp-PLA2 generates two proinflammatory mediators, lysophosphatidylcholine and oxidized nonesterified fatty acids, which play a role in the development of atheroscler...

Journal: :The Journal of clinical investigation 1999
A K Foreman-Wykert Y Weinrauch P Elsbach J Weiss

We have shown previously that a group IIA phospholipase A2 (PLA2) is responsible for the potent bactericidal activity of inflammatory fluids against many Gram-positive bacteria. To exert its antibacterial activity, this PLA2 must first bind and traverse the bacterial cell wall to produce the extensive degradation of membrane phospholipids (PL) required for bacterial killing. In this study, we h...

2018
Youxin Wang Bin Zhou Pingan Zhou Yan Yao Qinghua Cui Yingping Liu Jichun Yang Shouling Wu Xingquan Zhao Yong Zhou

Cerebral artery stenosis (CAS) is the most important causes of ischaemic stroke. Lipoprotein-associated phospholipase A2 (Lp-PLA2) plays 2 diverse roles in atherosclerosis (pro-inflammatory and anti-inflammatory), and the association between Lp-PLA2 mass and cardiovascular or cerebrovascular events is inconsistent among previous studies. A cross-sectional study including 2012 North Chinese adul...

Journal: :Archives of general psychiatry 1997
B M Ross C Hudson J Erlich J J Warsh S J Kish

BACKGROUND Magnetic resonance spectroscopy studies have suggested above-normal turnover of membrane phospholipids in brains of patients with schizophrenia. One possible explanation for these findings is increased activity of the phospholipid-catabolizing enzyme phospholipase A2 (PLA2). However, attempts to demonstrate higher PLA2 activity in the serum of subjects with schizophrenia have led to ...

Journal: :Antioxidants & redox signaling 2003
Rao Muralikrishna Adibhatla James F Hatcher Robert J Dempsey

Phospholipid degradation is an important promoter of neuronal death after transient cerebral ischemia. Phospholipid hydrolysis by phospholipase A2 (PLA2) after transient cerebral ischemia releases arachidonic acid. Arachidonic acid metabolism results in formation of reactive oxygen species, lipid peroxides, and toxic aldehydes (malondialdehyde, 4-hydroxynonenal, and acrolein). Citicoline (cytid...

Journal: :Gut 1997
M M Haapamäki J M Grönroos H Nurmi K Alanen M Kallajoki T J Nevalainen

BACKGROUND It has been suggested that phospholipase A2 (PLA2) has an essential role in the pathogenesis of inflammatory bowel diseases. AIMS This study aimed at identifying cells in intestinal and mesenteric tissue samples that might express group II phospholipase A2 (PLA2-II) at the mRNA and enzyme protein levels in patients with ulcerative colitis. PATIENTS AND TISSUE SAMPLES: Tissue sample...

2017
Ye Tian Huan Jia Sichen Li Yanmin Wu Li Guo Guojun Tan Bin Li

BACKGROUND Studies on stroke and lipoprotein-associated phospholipase A2 (Lp-PLA2) have produced conflicting results. OBJECTIVE The aim of the study was to assess the associations of Lp-PLA2 levels (mass and activity) with recurrent vascular events in patients with transient ischemic attack (TIA) and/or first ischemic stroke and with stroke in the general population. METHODS The MEDLINE, Em...

Journal: :The European journal of neuroscience 2001
K Arai Y Ikegaya Y Nakatani I Kudo N Nishiyama N Matsuki

Although it is well known that the hippocampal CA1 subfield is highly vulnerable to ischemic injury, cellular mechanisms leading to this neuronal degeneration are not fully understood. Using organotypic cultures of rat hippocampal slices, we determined whether phospholipase A2 (PLA2) is activated in response to ischemic conditions (OGD; oxygen and glucose deprivation). The PLA2 activity in the ...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2006
Frank D Kolodgie Allen P Burke Kristi S Skorija Elena Ladich Robert Kutys Addisalem Taye Makuria Renu Virmani

OBJECTIVE Although lipoprotein-associated phospholipase A2 (Lp-PLA2) has received recent attention as a biomarker of inflammation and risk for acute coronary events, its relative expression in coronary plaque phenotypes, including unstable lesions, has not been established. METHODS AND RESULTS Coronary segments (n=30) were prospectively collected from 25 sudden coronary death patients for imm...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید