The present manuscript describe simple, sensitive, rapid, accurate, precise and economical Q-absorbance ratio method for the simultaneous determination of cefpodoxime proxetil and ofloxacin in combined tablet dosage form. Absorbance ratio method uses the ratio of absorbances at two selected wavelengths, one which is an isoabsorptive point and other being the λ-max of one of the two components. ...

Solid Dispersions were prepared by solvent evaporation technique using microcrystalline cellulose, PEG 4000, PEG 6000, PVP-K30 and Gelucire 50/13. Further objective of the project was to develop fast release surface solid dispersion of glibenclamide and compressed at low pressure to form fast-melting pharmaceutical tablet. In this study, we used sodium starch glycolate for mouth dissolving natu...

A simple, rapid, and accurate high-performance thin-layer chromatography (HPTLC) method is described for the simultaneous determination of levofloxacin hemihydrate and ornidazole in tablet dosage form. The method is based on the HPTLC separation of the two drugs followed by densitometric measurements of their spots at 298 nm. The separation is carried out on Merck TLC aluminium sheets of silica...

The purpose of this study was to investigate coating process of tablets with the novel starch hydrolysate emulsion. The process was performed manually in a coating pan rotating 35 rpm, with a stream of dry air (40 - 45 degrees C). The coated tablets were of fairly good quality. A total tablet surface was calculated for evaluation of quantity of starch hydrolysate emulsion for one step of coatin...

A new, simple and sensitive Spectrophotometric Method in ultraviolet region has been developed for the determination of cilnidipine in bulk and in pharmaceutical formulations. Cilnidipine exhibits absorption maxima at 240 nm. The method obeys the Beer's law in the concentration range of 2 30 μg/ml. The method is accurate, precise and economical. The % recovery is greater than 99.86 100.67%. Thi...

Multiple compressed tablets are compressed tablets made by more than one compression cycle. They are usually prepared to separate physically or chemically incompatible ingredients or to produce repeat or prolong action of drug. Compression coating perform similar functions as sugar or film coating except consists of dry coating concept hence prevents certain drawbacks of aqueous and non aqueous...

from powder characterisation and how the data correlates to process performance and drug product quality in solid dosage form develop ment projects. Data from two development studies will be shown. The development and manufacturing of solid dosage forms relies heavily on powder material. API and tablet excipients are most often handled as a granular material. The powders are mixed and compresse...

Many patients especially children and elderly have difficulty in swallowing tablets and capsules and consequently unable to take medicine as prescribed. Almost 50% of the population is affected by such problem, resulting in the high incidence of non compliance and ineffective therapy. Most pharmaceutical forms for oral administration are formulated for direct ingestion, or for chewing, or for p...