The virulence of gram-positive bacterium Listeria monocytogenes depends on its capacity to infect non-professional phagocytes and proliferate inside them. Listerias captured by mononuclear phagocytic cells during the infectious process are resistant lysosomal digestion can macrophages. Internalin B (InlB), one key pathogenicity factors L. monocytogenes, interacts with mammalian receptors c-Met ...

Mononuclear phagocytes are usually cultured on a glass or plastic surface to which these cells readily become attached and spread. Both glass and plastic have, however, the disadvantage that it is very difficult to recover mononuclear phagocytes without injuring the cells. The present paper describes a method for culturing on a Teflon membrane to which cells do not attach and from which they ca...

Many cells possess the ability to engulf and incorporate particles by phagocytosis. This active process is characteristic of microorganisms as well higher order species. In mammals, monocytes, macrophages, microglia are among so-called professional phagocytes. addition, such fibroblast chondrocytes classified nonprofessional Professional phagocytes play important roles in both innate adaptive i...

Johne's disease is a condition that refers to chronic granulomatous enteritis in ruminants. It is believed that survival and replication of Mycobacterium (M.) paratuberculosis in mononuclear phagocytes plays an important role in the pathogenesis of Johne's disease. However, it is not clear how M. paratuberculosis survives for long time periods in mononuclear phagocytes, nor is it clear which fa...

Pathologically swollen lymph nodes (LNs), or buboes, characterize Yersinia pestis infection, yet how they form and function is unknown. We report that colonization of the draining LN (dLN) occurred due to trafficking of infected dendritic cells and monocytes in temporally distinct waves in response to redundant chemotactic signals, including through CCR7, CCR2, and sphingosine-1-phospate (S1P) ...

Cryptococcus neoformans and C. gattii are fungal pathogens that cause life-threatening disease. These fungi commonly enter their host via inhalation into the lungs where they encounter resident phagocytes, including macrophages and dendritic cells, whose response has a pronounced impact on the outcome of disease. Cryptococcus has complex interactions with the resident and infiltrating innate im...

Engulfment of apoptotic cells is predominantly executed by phagocytes via the recognition of "eat me" signals like phosphatidylserine (PS). Various PS-specific receptors exist on phagocytes, including Tyro3, Axl, and MerTK receptor tyrosine kinases (TAMs), T-cell immunoglobulin and mucin domain containing 1 and 4 (TIM1/4), and the newly identified CD300 family. The aim of the present auto-comme...

Citation: Hoang KV, Rajaram MVS, Curry HM, Gavrilin MA, Wewers MD and Schlesinger LS (2018) Complement Receptor 3-Mediated Inhibition of Inflammasome Priming by Ras GTPase-Activating Protein During Francisella tularensis Phagocytosis by Human Mononuclear Phagocytes. Front. Immunol. 9:561. doi: 10.3389/fimmu.2018.00561 complement receptor 3-Mediated inhibition of inflammasome Priming by ras gTPa...

The immunomodulator interleukin-1 (IL-1) is found to be an astroglial growth factor during development of the mammalian brain. In vitro studies indicate that ameboid microglia, a class of brain mononuclear phagocytes, are the likely source of IL-1. Examination of different brain regions during development shows IL-1 production only after the appearance of ameboid microglia. These observations s...

Muscle injury triggers inflammation in which infiltrating mononuclear phagocytes are crucial for tissue regeneration. The interaction of the CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axis that guides phagocyte infiltration is incompletely understood. Here, we show that CX3CR1 deficiency promotes muscle repair and rescues Ccl2(-/-) mice from impaired muscle regeneration as a result of altered macrop...