نتایج جستجو برای: ph sensitive nanoparticles

تعداد نتایج: 539402  

Journal: :ACS nano 2012
Aleksandar F Radovic-Moreno Timothy K Lu Vlad A Puscasu Christopher J Yoon Robert Langer Omid C Farokhzad

Bacteria have shown a remarkable ability to overcome drug therapy if there is a failure to achieve sustained bactericidal concentration or if there is a reduction in activity in situ. The latter can be caused by localized acidity, a phenomenon that can occur as a result of the combined actions of bacterial metabolism and the host immune response. Nanoparticles (NP) have shown promise in treatin...

Journal: :The Analyst 2015
Aleksandra Jaworska Lauren E Jamieson Kamilla Malek Colin J Campbell Jaebum Choo Stefan Chlopicki Malgorzata Baranska

The intracellular pH plays an important role in various cellular processes. In this work, we describe a method for monitoring of the intracellular pH in endothelial cells by using surface enhanced Raman spectroscopy (SERS) and 4-mercaptobenzoic acid (MBA) anchored to gold nanoparticles as pH-sensitive probes. Using the Raman microimaging technique, we analysed changes in intracellular pH induce...

2014
Kethirabalan Chitra Gurusamy Annadurai

Simple, nontoxic, environmental friendly method is employed for the production of silver nanoparticles. In this study the synthesized nanoparticles UV absorption band occurred at 400 nm because of the surface Plasmon resonance of silver nanoparticles. The pH of the medium plays important role in the synthesis of control shaped and sized nanoparticles. The colour intensity of the aqueous solutio...

2018
Zheng Huang Dong-Mei Zhao Xuan Deng Ji Zhang Yi-Mei Zhang Xiao-Qi Yu

The studies of bolaamphiphile-based nanoparticles as delivery vectors are still rudimentary and under development. In this study, several asymmetric bolaamphiphiles containing lysine and another moiety with special functions, such as pH-sensitive or cell-targeting property, were designed and synthesized. The potentials of these bolaamphiphile-based nanoparticles as versatile vectors for both nu...

Journal: :iranian journal of pharmaceutical research 0
hongfei liu jiangsu university shuangshuang shi jiangsu university weisan pan shenyang pharmaceutica university changshan sun shenyang pharmaceutical university xiaomian zou shenyang pharmaceutical university min fu jiangsu university

the main objective of this study was to investigate biocompatibility and provide in vivo pharmacological and toxicological evidence for further investigation of the possibility of ph sensitive ion exchange resin microsphere for clinical utilizations. acute toxicity study and general pharmacological studies were conducted on the ph sensitive ion exchange resin microsphere we prepared. the genera...

Journal: :International journal of pharmaceutics 2011
Xue-qing Wang Jie-ming Fan Ya-ou Liu Bo Zhao Zeng-rong Jia Qiang Zhang

Sorafenib is slightly absorbed in the gastrointestinal tract due to its poor solubility in water. To improve its absorption, a novel nanoparticulate formulation-nanomatrix was used in the study. The nanomatrix was a system prepared from a porous material Sylysia(®) 350 and a pH sensitive polymer Eudragit(®). The formulations were optimized by orthogonal design (L(9)(3(4))) and their bioavailabi...

2017
Yi-Huang Hsueh Ping-Han Tsai Kuen-Song Lin

The antimicrobial properties of CuO nanoparticles have been investigated, but the underlying mechanisms of toxicity remain the subject of debate. Here, we show that CuO nanoparticles exhibit significant toxicity at pH 5 against four different Staphylococcus aureus (S. aureus) strains, including Newman, SA113, USA300, and ATCC6538. At this pH, but not at pH 6 and 7, 5 mM CuO nanoparticles effect...

Journal: :Nanoscale 2015
Siyu Liu Ning Zhao Zhen Cheng Hongguang Liu

Amino-functionalized fluorescent carbon dots have been prepared by hydrothermal treatment of glucosamine with excess pyrophosphate. The produced carbon dots showed stabilized green emission fluorescence at various excitation wavelengths and pH environments. Herein, we demonstrate the surface energy transfer between the amino-functionalized carbon dots and negatively charged hyaluronate stabiliz...

2016
Abdulaziz M Aldayel Youssef W Naguib Hannah L O'Mary Xu Li Mengmeng Niu Tinashe B Ruwona Zhengrong Cui

There has been growing interest in utilizing small interfering RNA (siRNA) specific to pro-inflammatory cytokines, such as tumor necrosis factor-α ( TNF-α), in chronic inflammation therapy. However, delivery systems that can increase the distribution of the siRNA in chronic inflammation sites after intravenous administration are needed. Herein we report that innovative functionalization of the ...

Journal: :Langmuir : the ACS journal of surfaces and colloids 2015
Susanne van Berkum Pieter D Biewenga Suzanna P Verkleij J Hans B A van Zon Kristel W M Boere Antara Pal Albert P Philipse Ben H Erné

Hydrogels that are pH-sensitive and partially cross-linked by cobalt ferrite nanoparticles exhibit remarkable remanent magnetization behavior. The magnetic fields measured outside our thin disks of ferrogel are weak, but in the steady state, the field dependence on the magnetic content of the gels and the measurement geometry is as expected from theory. In contrast, the time-dependent behavior ...

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