OBJECTIVES To investigate the combined effects of Helicobacter pylori infection and traditional risk factors for peptic ulcer. METHODS A case-control study was conducted in chemical factories in Shanghai, China. The cases were 500 people with peptic ulcer randomly selected from all staff who met the selection criteria. The controls were 500 employees randomly selected from the same factories ...

Background: It is not yet known which types of Toll-like receptors (TLRs) are most effective in Helicobacter pylori (H. pylori) recognition. It is also not known which gastric zones have the most prominent roles in TLR-mediated bacterial recognition. The aim of this work was to analyze the expression of TLR2 and TLR4 in biopsy specimens from H. pylori-infected patients. Methods: Thirty-eight...

Background& Aims: Gastric adenocarcinoma has been considered as an infectious disease since 1994, when the Helicobacter pylori (H. pylori) infection categorized as a definite class I human carcinogen. H. pylori uses extensive numbers of virulence factors to overcome host defence mechanisms. One independent H. pylori factor that plays an important role in determining H.pylori pathogenesisis vacu...

OBJECTIVES H. pylori infection has been associated with some autoimmune disorders. The aim of this study was to evaluate the serum concentrations of rheumatoid factor and anti-nuclear antibodies in H. pylori-infected peptic ulcer patients, H. pylori-infected asymptomatic carriers and a healthy control group. METHODS A Total of 100 H. pylori-infected peptic ulcer patients, 65 asymptomatic carr...

AIMS To investigate the association of cagA positivity and non-opsonic neutrophil activation capacity in wild-type Helicobacter pylori strains with peptic ulcer disease or chronic gastritis only. METHODS Helicobacter pylori were isolated from antral biopsies of 53 consecutive patients with chronic antral gastritis, of whom 24 had peptic ulcer disease endoscopically. The presence of cagA, a ma...

Helicobacter pylori infection is now accepted as the major cause of severe gastritis-associated diseases, including peptic ulcer and gastric cancer. In the current study, we decided to determine the dupA and OipA genotypes in H. pylori strains isolated from patients with gastrointestinal disorders and to evaluate whether these genes are associated with the severity of the gastroduodenal disease...

Peptic ulcer disease including both gastric and duodenal ulcer form a substantial part of patients seeking surgical opinion world-wide. The concept of acid in peptic ulcer disease, which was the basis of treatment of peptic ulcer was revolutionized by the discovery of H2-receptor antagonists, that led to the principle of acid suppression therapy for duodenal ulcer which followed decades of pref...

background: acute upper gi bleeding (ugib) is a common medical emergency situation. in the past years, important changes have taken place that might have influenced the incidence, etiology, and outcome for patients with acute ugib. the aim of this study was to determine current time trends in the incidence, management, and prognosis of patients with ugib in 14 years period in a region in center...

background: in developing countries primary antibiotic-resistance and poor compliance are the main causes of helicobacter pylori (hp) eradication failure of standard regimens. aim: to investigate eradication rate, patient's compliance and tolerability of a 1-wk azithromycin based quaruple therapy versus the 2-wk conventional therapy. materials and methods: a total of 129 hp-positive patients we...

background acute upper gastrointestinal bleeding (ugib) is a common medical emergency and is known as one of the main causes of mortality and morbidity. this research was conducted to study the causes and risk factors for ugib, in a referral center. methods in this cross sectional study, carried out in a one year period, all patients with acute ugib living in khorramabad city and surrounding ar...